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1. • Quality Inn & Suites

     Hotel

     15 on TripAdvisor

      · (803) 854-7075
     
   • Best Western Plus Santee Inn

     Hotel · $$ · 471.08mi

     Open

      · (803) 854-3089
   • Holiday Inn Santee, an IHG Hotel

     Hotel · 470.91mi

     Open · 315 on TripAdvisor

     139 Bradford Blvd · (803) 854-9800
     
   • Swamp Fox Motel

     Hotel, Motel · 470.48mi

     Open · 2 on TripAdvisor

     326 Bass Dr · (803) 854-3378
     
   • OYO Hotel Santee SC Lake Marion

     Hotel · 470.75mi

     Open · 1 on Yelp

     628 Bass Dr · (628) 263-0418
     
   • Econo Lodge

     Hotel · $$ · 471.28mi

     Open · 16 on Yelp

     9112 Old Number Six Hwy · (803) 854-3870
     
   • Comfort Inn & Suites Santee I-95

     Hotel · 470.94mi

     Open · 243 on TripAdvisor

     221 Britain St · (803) 854-4104
     
   • Econo Lodge

     Motel, Hotel · 470.78mi

     Open · 158 on TripAdvisor

      · (803) 854-3870
     
   • Knights Inn Santee

     Hotel · 470.99mi

     Open · 7 on Yelp

     249 Britain St · (803) 854-3221
     
   • Hampton Inn Santee-I-95

     Hotel · 471.18mi

     Open · 1088 on TripAdvisor

     9060 Old Number Six Hwy · (803) 854-2444
     
   • Quality Inn & Suites

     Hotel · 470.73mi

     Open · 2 on Yelp

     8929 Old Number Six Hwy · (803) 854-7075
     
   • Super 8 by Wyndham Santee

     Hotel, Motel

     364 on TripAdvisor

     9125 SC-6 · (803) 757-4521
     
   • Clarion Inn Santee I-95

     Hotel · 471.12mi

     Open · 165 on TripAdvisor

     123 Mall St · (239) 839-4045
     
   • Lenora's Santee Resort

     Hotel, Resort

     5275 Dingle Pond Rd · (803) 478-9675
   • Fairfield Inn & Suites Santee

     Hotel

     195 on TripAdvisor

     9074 Old Number Six Hwy · (803) 854-7070