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1. • EC Reed's Mercantile and Hotel

     Hotel, Boutique Hotel · 421.24mi

     Open · 6 on TripAdvisor

     301 1st St · (573) 238-3276
     
   • Town House Inn

     Hotel, Inn · $$ · 403.37mi

     Closed · 6 on Yelp

     517 E Jackson Blvd · (573) 243-3577
     
   • Drury Inn & Suites Jackson, MO

     Hotel · 400.61mi

     Open · 297 on TripAdvisor

     225 Drury Ln · (573) 243-9200
     
   • Drury Plaza Hotel Cape Girardeau Conference Center

     Hotel

     175 on TripAdvisor

     3351 Percy Dr · (573) 334-7151
     
   • Drury Inn & Suites Cape Girardeau

     Hotel · 401.9mi

     Open · 284 on TripAdvisor

     3303 Campster Dr · (573) 339-9500
     
   • Comfort Inn Perryville

     Hotel, Motel · $$ · 404.21mi

     Open

     1517 S Perryville Blvd · (573) 547-1727
   • Econo Lodge

     Hotel · $$ · 438.01mi

     Open · 8 on Yelp

     913 Outer Rd · (573) 624-7400
     
   • Auburn Place Hotel & Suites

     Motel, Hotel

     531 on TripAdvisor

     3265 William St · (573) 651-4486
     
   • Candlewood Suites Cape Girardeau, an IHG Hotel

     Hotel, Conference Center · 401.92mi

     Open · 142 on TripAdvisor

     485 S Mt Auburn Rd · (573) 334-6868
     
   • Madison Inn Lodge

     Motel, Hotel · 429.11mi

     Open · 63 on TripAdvisor

     730 Plaza Dr · (573) 783-2500
     
   • Town House Inn Cape Girardeau

     Hotel

     47 on TripAdvisor

     505 N Kingshighway · (573) 335-2700
     
   • Comfort Suites Jackson/Cape Girardeau

     Hotel · 401.47mi

     Open · 172 on TripAdvisor

     2904 S Old Orchard Rd · (573) 204-0014
     
   • Budget Inn

     Hotel, Motel · $$

     1 on Yelp

     221 S Kingshighway St · (573) 547-4516
     
   • Pear Tree Inn Cape Girardeau Near the Medical Center

     Hotel · 401.59mi

     Open · 229 on TripAdvisor

     3248 William St · (573) 334-3000
     
   • Quality Inn

     Hotel · 400.73mi

     Open · 433 on TripAdvisor

     2011 N Kingshighway St · (573) 339-0808