Search results
Jan 5, 2024 · Unlike mRNA vaccines, which are a form of immune-based therapy that provides delayed protection and also requires periodic administration due to viral mutation and/or waning immunity, the stapled lipopeptides developed by Walensky's lab act directly on SARS-CoV-2, the coronavirus responsible for COVID-19, interfering with its ability to infect ...
Loren David Walensky. The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause cancer. To achieve these objectives, we take a multidisciplinary ...
Jan 17, 2024 · Main. BCL-2-associated X protein (BAX) is a pro-apoptotic BCL-2 family protein that resides in the cytosol as a latent monomer until triggered to undergo a conformational change, which drives its ...
Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR. Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med 2012; 4:148ra117. PubMed; Walensky LD. Interview with Loren D Walensky.
Aug 27, 2019 · 27. Loren Walensky. @LorenWalensky. ·. Jun 3. 23 years ago relapsed cancer led to her becoming one of my first childhood cancer patients. She overcame more relapses since. Now this warrior-survivor is celebrating her wedding day. Nothing could keep me away from witnessing this day we worried might never come.
Loren Walensky, MD, PhD. Professor of Pediatrics, Dana-Farber Cancer Institute Director of the Harvard/MIT MD-PhD Program. Contact Information. ... Walensky Lab Website.
The mitochondrial lipid trans-2-hexadecenal (t-2-hex) sensitizes BAX activation by covalent derivatization of cysteine 126 (C126). In this study, we performed a disulfide tethering screen to discover C126-reactive molecules that modulate BAX activity. We identified covalent BAX inhibitor 1 (CBI1) as a compound that selectively derivatizes BAX ...
