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  1. Janeway Lesion. A Janeway lesion is a dark spot, usually circular, that occurs on the soles of the foot. It may also appear on the palms of the hands. Upon close examination, you will see an abscess in the area of the Janeway lesion. A Janeway lesion is not painful. Cause A Janeway Lesion is caused the a blood clot that causes sepsis.

  2. Janeway lesions can cause very different symptoms and discomforts, depending on where they occur and what the underlying cause is. Typically, the skin changes appear on the hands and feet. There, reddish-brown spots or lumps form, which can reach a size of one to five millimeters and which are accompanied by increasing itching.

  3. Apr 18, 2019 · Janeway lesions and Osler’s nodes are both classic stigmata of endocarditis, but distinguishing the two can be difficult. Janeway lesions are nontender hemorrhagic macules or papules located on palms, soles, and thenar and hypothenar eminences. Osler’s nodes are painful violaceous nodes typically found on fingers and toes.

  4. May 25, 2022 · Petechiae are the most common cutaneous manifestation of IE, 20-40% of patients experience petechiae on the extremities and mucous membranes such as the palate and conjunctivae. Other skin findings of IE include splinter hemorrhages within the nail as well as Janeway lesions and Osler nodes. Janeway lesions are more commonly found in acute IE ...

  5. This article concerns a patient with infectious endocarditis due to Diplococcus pneumoniae, who had tender vesicular lesions thought to be Osler's nodes and a nontender erythematous nodule on the foot compatible with a Janeway's lesion. The original comments by William Osler and Edward Janeway are presented, and the literature following their ...

  6. Jun 25, 2022 · Swelling in the feet, legs or belly; A new or changed whooshing sound in the heart (murmur) Less common endocarditis symptoms can include: Unexplained weight loss; Blood in the urine; Tenderness under the left rib cage (spleen) Painless red, purple or brown flat spots on the soles bottom of the feet or the palms of the hands (Janeway lesions)

  7. USA.gov. Endocarditis was first described by William Osler in 1885. It is an inflammatory process that affects the endocardium and may have an infective or noninfective (eg, systemic lupus erythematosus) origin. It is uncommon in the western world (22 cases per million), but more prevalent in developing countries.

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