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  1. Aug 30, 2022 · The pattern of pigmentation may suggest a particular implicated drug; localised pigmentation on the face, lip, or genitalia may suggest a resolved fixed drug eruption. Flagellate pigmentation is a feature of a bleomycin eruption. The following table details the clinical features with reference to each class of drug.

  2. Oct 9, 2022 · Fixed food eruptions. Fixed eruptions can also occur following ingestion of food, rather than a drug, and these are referred to as a fixed food eruption. Quinine, contained in tonic water, is a well-known cause . Other known foods triggers include nuts, licorice, strawberries, asparagus, and lentils.

  3. Fixed drug eruption. Fixed drug eruption is an adverse drug reaction that usually occurs in the same site/s on the skin every time the medication is taken. A fresh lesion is a well defined targetoid plaque, with a dusky red raised area of skin and sometimes a central blister. Fixed drug eruption is not usually very extensive.

  4. Mar 1, 2020 · The duration and onset of lichenoid drug eruptions are often dependent on the causative agent and dosage. Lichenoid drug eruptions occur most often in individuals between the age of 57 to 66 years and can have an average latent period of one year between the beginning of the medication treatment and the onset of an eruption . This medication ...

  5. Challenge tests are safe in fixed drug eruption, but are absolutely contraindicated in Stevens-Johnson syndrome and toxic epidermal necrolysis. The approach to the treatment of the more serious adverse cutaneous drug reactions, including angioedema/anaphylaxis, exfoliative dermatitis erythroderma and toxic epidermal necrolysis is reviewed.

  6. Apr 15, 2021 · Fixed drug eruption (FDE) is a type of adverse drug reaction manifesting on the skin. Patients with FDE present with the sudden onset of well-demarcated macules or edematous plaques on the skin or mucous membranes, accompanied by itching or burning [1,2]. There may also be vesicles, bullae, or denuded skin .

  7. Aug 23, 2022 · Introduction. Fixed drug eruptions (FDEs) are cutaneous manifestations that are associated with the usage of certain drugs. There are over 100 drugs associated with FDEs, but some of the most commonly implicated drugs include trimethoprim-sulfamethoxazole (and other sulfonamides), naproxen, ibuprofen, tetracyclines, other antibiotics (ampicillin, metronidazole), and barbiturates.

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