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Aug 30, 2022 · The pattern of pigmentation may suggest a particular implicated drug; localised pigmentation on the face, lip, or genitalia may suggest a resolved fixed drug eruption. Flagellate pigmentation is a feature of a bleomycin eruption. The following table details the clinical features with reference to each class of drug.
Medical Care. The main goal of treatment is to identify the causative agent and avoid it. Treatment for fixed drug eruptions (FDEs) otherwise is symptomatic. Systemic antihistamines and topical corticosteroids may be all that are required. In cases in which infection is suspected, antibiotics and proper wound care are advised.
Apr 8, 2024 · INTRODUCTION. Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug. Acute FDE usually presents with a single or a small number of dusky red or violaceous plaques that resolve leaving postinflammatory hyperpigmentation ( picture 1A-C ).
The term bullous drug eruptions refers to adverse drug reactions that result in fluid-filled blisters or bullae. Blistering can be due to various medications, prescribed or over-the-counter, natural or synthetic. Blistering may be localised and mild, or widespread and severe, even life-threatening.
Medications commonly reported to trigger a lichenoid drug eruption include: Antihypertensives – ACE inhibitors, beta-blockers, nifedipine, methyldopa. Diuretics – hydrochlorothiazide, frusemide, spironolactone. Non-steroidal anti-inflammatory drugs ( NSAIDs) Phenothiazine derivatives. Anti-convulsants – carbamazepine, phenytoin.
Abstract. Severe drug eruptions are rare, life-threatening events. The management begins with the withdrawal of the suspect drug (s). We recently confirmed that an earlier withdrawal of drugs with short elimination half-life was associated with a better survival of patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).
Non-immunological drug eruptions. These may be due to idiosyncratic reaction, hereditary enzyme deficiency, dose dependent cumulation, irritancy or toxicity. Examples include: Eczema craquelé aggravated by diuretics. Cutaneous atrophy, striae and telangiectasia due to topical or systemic steroids.
