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Learn more about CLOVES syndrome, a rare vascular anomaly that can affect a child's soft tissues, vessels, bones, skin and more from Boston Children's Hospital.
CLOVES syndrome is a rare condition that is primarily characterized by congenital overgrowth of fatty tissue; malformations of the vascular system (the vessels that carry blood and lymph throughout the body); epidermal nevi; and spinal or skeletal abnormalities.
Aug 5, 2020 · CLOVES syndrome is a recently described rare disorder characterized by tissue overgrowth and complex vascular anomalies. CLOVES stands for congenital lipomatous (fatty) overgrowth, vascular malformations, epidermal nevi and scoliosis/skeletal/spinal anomalies.
Mar 4, 2024 · CLOVES syndrome is a rare disease that causes skin overgrowths in unborn children. Learn about the PIK3CA gene mutation and what to expect as a parent.
CLOVES syndrome is a rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs.
CLOVES Syndrome is an overgrowth syndrome with complex vascular anomalies. CLOVES stands for Congenital, Lipomatous Overgrowth, Vascular malformations, Epidermal nevi and Scoliosis/Skeletal/Spinal anomalies. The syndrome was described independently by Saap et al. and Alomari [1,2].
What Is CLOVES Syndrome? CLOVES syndrome is a very rare genetic disorder. It’s named for the combination of vascular, skin, spinal, and bone or joint abnormalities that make up the syndrome: C: Congenital (present at birth) L: Lipomatous (referring to lipomas, soft fatty masses often found on one or both sides of the back and belly)
Jun 9, 2024 · CLOVES syndrome is one of a group of syndromes known as overgrowth syndromes. CLOVES is an acronym and each letter represents a characteristic seen in the syndrome: CLO: Congenital Lipomatous Overgrowth. Congenital means that the lesion is present when the child is born. Lipomatous growths are large collections or masses of fatty tissue.
CLOVES syndrome is the most common overgrowth syndrome associated with a PIK3CA variant, also known as PROS (for PIK3CA-related overgrowth spectrum), affecting over 500 patients in France.
Jul 31, 2017 · CLOVES stands for Congenital Lipomatous assymetric Overgrowth, Vascular malformations, Epidermal nevi and Skeletal and spinal anomalies. This is similar to fibroadipose hyperplasia (FH) with more prominent blood vessel overgrowth, nevi (moles) and bone and spine problems.
