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Aug 23, 2023 · Overuse of empirical intravenous antibiotics in neonates in high-income countries (HICs) is well documented. The Kaiser Permanente neonatal early-onset sepsis (EOS) calculator is an evidence-based sepsis risk assessment tool that has demonstrated potential to reduce antibiotic usage in this population. The incidence of early-onset sepsis in most HICs is 0.4–0.8 per 1000 live births. The ...
Objective To compare management recommendations of the National Institute for Health and Care Excellence (NICE) guidelines with the Kaiser Permanente sepsis risk calculator (SRC) for risk of early onset neonatal sepsis (EONS). Design Multicentre prospective observational projection study. Setting Eight maternity hospitals in Wales, UK. Patients All live births ≥34 weeks gestation over a 3 ...
Feb 5, 2023 · Early onset neonatal sepsis (EONS) is an infrequent (global incidence rate of 0.3–0.9/1000 in terms of near-term live births) but serious illness.1,2 It is defined as blood or cerebrospinal fluid (CSF) culture-proven infection within 72 h of birth.3 Group B streptococcus (GBS) and Escherichia Coli are the most frequent causative pathogens, with the mechanism of pathogenesis attributed to the ...
Apr 29, 2023 · To evaluate the effect of implementation of the Kaiser Permanente (KP) early onset sepsis (EOS) calculator in infants born at 34 week’s gestation or more on antibiotic utilization and length of ...
Jan 1, 2024 · The Kaiser Permanente neonatal early-onset sepsis (EOS) calculator is an evidence-based sepsis risk assessment tool that has demonstrated potential to reduce antibiotic usage in this population. The incidence of early-onset sepsis in most HICs is 0.4–0.8 per 1000 live births.
The primary outcome of interest was a decrease in the use of antibiotics for EOS in neonates 34 weeks' gestation or more. Results: Over a 4-month period, prior to sepsis calculator implementation, antibiotic use for suspected EOS was 11% and blood culture was done on 14.8% of live births. After implementation of the sepsis calculator and ...
Dec 22, 2019 · The Kaiser-Permanente calculator has been shown to reduce antibiotic usage in several international settings. We carried out a systematic review using a modified cluster technique, snowballing from studies citing the 2017 JAMA pediatrics paper describing the calculator and its implementation.
