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9 hours ago · Background Rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is one of the first line treatments for diffuse large B-cell lymphoma (DLBCL). Rituximab comprises most of the treatment cost for this regimen; therefore, biosimilars, such as rituximab-abbs are crucial to provide affordable care. Although rituximab-abbs was studied primarily in follicular lymphoma ...
9 hours ago · The main difference between Cluster 2 and 3 was hepatic encephalopathy, found in 89% of the patients in Cluster 2 and almost no patients in Cluster 3 (Fig. 5A, B and Table S3). Importantly, a significant prognostic value of AD-strat was revealed by exploring the cumulative incidence of ACLF and death over 90-day follow-up (Fig. 5 C).
9 hours ago · Major depressive disorder (MDD) is a mood disorder that has become a global health emergency according to the World Health Organization (WHO). It affects 280 million people worldwide and is a leading cause of disability and financial loss. Patients with MDD present immunoendocrine alterations like cortisol resistance and inflammation, which are associated with alterations in neurotransmitter ...
9 hours ago · TNF inhibitors (TNFi) have revolutionized the therapeutic management of various chronic immune-mediated inflammatory diseases. Despite their known benefits, these therapies are related to paradoxical adverse effects (PAEs), including paradoxical psoriasis (PP). Although the underlying mechanism remains somewhat unclear, some theories suggest that genetic factors, particularly certain single ...
9 hours ago · Biological hazards are the cause of the majority of human diseases. For example, bacteria cause cholera, tuberculosis, leprosy, relapsing fever and many diarrhoeal diseases; viruses are responsible for hepatitis B and C, HIV, measles and polio; and there are many diseases caused by parasites.
