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Jul 15, 2023 · What Causes Sodium Nitrite Toxicity? What Are the Symptoms of Sodium Nitrite Toxicity? What Are Safety Measures for Sodium Nitrite?
Oct 27, 2022 · Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.
Toxicity. Sodium nitrite is toxic. The LD 50 in rats is 180 mg/kg and in humans LD Lo is 71 mg/kg. The mechanism by which sodium nitrite causes death is methemoglobinemia. The oftentimes severe methemoglobinemia found in sodium nitrite poisoning cases results in systemic hypoxia, metabolic acidosis, and cyanosis.
Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death. The majority of reports on sodium nitrite poisonings have been the result of unintentional exposures. We report a case of an intentional fatal overdose of sodium nitrite.
Mar 17, 2022 · Sodium nitrite toxicity is capable of causing severe methemoglobinemia with high mortality. Prompt identification is crucial. We discuss the important implications in regard to media coverage, imitative suicide, and accessibility of sodium nitrite.
The incidence of intentional self-poisoning with sodium nitrite has been increasing since 2017. Many of these exposures result in toxicity requiring antidotal therapy, and a high mortality rate was observed.
Acute acquired methemoglobinemia is the most important adverse health effect caused by excessive nitrate/nitrite exposure. The known toxic effects from nitrate exposure result from the conversion of nitrate to nitrite.
