Search results
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.
Oct 15, 2021 · The purpose of this document is to provide a centralized resource for key information on the CYP2D6 gene, allele function, and phenotype prediction, as well as an overview of the recent literature reporting the allele and phenotype frequencies.
- Megan Kane
- 2021/10/15
- NCBI, Email: vog.hin.mln.ibcn@sgm
Oct 30, 2020 · Abstract. Cytochrome P450 2D6 ( CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology.
- Christopher Taylor, Ian Crosby, Vincent Yip, Peter Maguire, Munir Pirmohamed, Richard M. Turner
- 10.3390/genes11111295
- 2020
- Genes (Basel). 2020 Nov; 11(11): 1295.
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) contributes to 2% and 0.7% of the overall hepatic and intestinal cytochrome P450 enzyme, respectively, and is estimated to be responsible for metabolism of 25% of commonly prescribed drugs (e.g., antidepressants, antipsychotics, opioids, beta blockers). Significant interpatient variability ...
- Emily J. Cicali, D. Max Smith, Benjamin Q. Duong, Lukas G. Kovar, Larisa H. Cavallari, Julie A. John...
- 10.1002/cpt.1768
- 2020
- 2020/07
CYP2D6 is a member of the cytochrome P450 (CYP450) family of enzymes that metabolize many drugs with a narrow therapeutic window. Learn about the genetic variants, phenotypes, and clinical implications of CYP2D6 polymorphism.
Sep 6, 2022 · 32 Citations. Metrics. Abstract. Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance...
People also ask
What does CYP2D6 stand for?
What is the CYP2D6 gene?
What is CYP2D6 4?
What is CYP2D6 polymorphism?
CYP2D6 is a polymorphic enzyme involved in drug metabolism and susceptibility to cancer. Learn about its genetic variants, substrates, and effects of pregnancy and postnatal age on its activity.
