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Determined to develop a gaseous drug that allows patients to tolerate the difficulties of surgery, Dr. Bolton (Boris Karloff) devises numerous opium-based remedies, which he tests on himself. His experiments fail miserably in trials performed for his colleagues -- who include his own son, Jonathan (Francis Matthews) -- and Bolton is dismissed from his position. Having developed an addiction to opium, Bolton finds work treating the poor but falls in with grave robbers in order to get drugs. Wikipedia