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Dr. Ron Wellesley (John Forsythe) is having a clandestine affair with Lisa (Reta Shaw), the wife of Frank Manning (Richard Kiley), one of his patients. When Frank finds out and confronts Wellesley about it, the physician makes a devious plan to kill his patient. A careful and exacting type, Wellesley thinks he has committed the perfect crime. However, he still has to deal with relentless Lt. Proctor (Wendell Burton) and the clever Nurse Regis (Joseph Campanella).