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- Season 5 overviewSep 25, 2019-Apr 15, 202020 episodesSeason 5 episodes20. A Needle in the Heart Apr 15, 2020
- Dr. Crockett is visited by two New Orleans detectives who have questions about his past.
- 19. Just a River in Egypt Apr 8, 2020
- Dr. Charles evaluates a teen who is brought into the E.D. after an apparent fall off an overpass.
- 18. In the Name of Love Mar 25, 2020
- Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes.
- 17. The Ghosts of the Past Mar 18, 2020
- Dr. Manning and Dr. Charles help a child who is no stranger to the ED.
- 16. Who Should Be the Judge Mar 4, 2020
- A convicted murderer's escape hits close to home when several team members end up in danger.
- 15. I Will Do No Harm Feb 26, 2020
- Dr. Charles and Dr. Manning treat a patient who is invested in pretending to be someone else.
- 14. It May Not Be Forever Feb 12, 2020
- Dr. Manning and Dr. Marcel disagree over an abusive husband; Dr. Halstead struggles with ethics.
- 13. Pain Is for the Living Feb 5, 2020
- Two brothers are rushed into the hospital, leaving the staff to piece together what transpired.
- 12. Leave the Choice to Solomon Jan 22, 2020
- The team deals with the aftermath of a school bus crash; Maggie helps a friend in need.
- 11. The Ground Shifts Beneath Us Jan 15, 2020
- After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger.
- 10. Guess It Doesn't Matter Anymore Jan 8, 2020
- Dr. Halstead is thrown into turmoil when a former patient resurfaces; April considers confessing.
- 9. I Can't Imagine the Future Nov 20, 2019
- April receives unfortunate news that makes her question her future with Ethan.
- 8. Too Close to the Sun Nov 13, 2019
- Maggie gets unsettling news about a new friend and breaks protocol to support him.
- 7. Who Knows What Tomorrow Brings Nov 6, 2019
- Dr. Charles and Dr. Halstead sink their teeth into a bloodthirsty case.
- 6. It's All in the Family Oct 30, 2019
- Dr. Manning's actions with a recent patient lead to serious repercussions; April and Noah disagree.
- 5. Got a Friend in Me Oct 23, 2019
- Dr. Choi and Dr. Marcel don't see eye to eye over the treatment of a patient's chronic pain.
- 4. Infection, Part II Oct 16, 2019
- An apartment complex is forced into quarantine when cases of a deadly virus turn into an epidemic.
- 3. In the Valley of the Shadows Oct 9, 2019
- Dr. Choi and Dr. Charles have tough decisions to make about a patient; Dr. Marcel and April clash.
- 2. We're Lost in the Dark Oct 2, 2019
- A power outage at Med puts patients at risk and tests the skills of the staff.
- 1. Never Going Back to Normal Sep 25, 2019
- Will and Natalie battle for their lives after a car accident.