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- Season 4 overviewSep 18-Nov 20, 200813 episodesSeason 4 episodes1. Mac & Dennis: Manhunters Sep 18, 2008
- Dee and Charlie develop a cannibalistic hunger after mistakenly eating some of Frank's human meat.
- 2. The Gang Solves the Gas Crisis Sep 18, 2008
- Mac, Dennis and Charlie invest in barrels of gasoline and sell them door to door.
- Frank and Mac judge a competition to find Paddy's next top model; creating a YouTube sensation.
- 4. Mac's Banging the Waitress Sep 25, 2008
- The waitress has a new boyfriend; Dennis tries to convince Charlie that they are best friends.
- 5. Mac and Charlie Die, Parts 1 and 2 Oct 2, 2008
- After Mac's father is released from prison, Mac and Charlie stage their own deaths.
- 6. Mac and Charlie Die, Part 2 Oct 2, 2008
- After Mac's father is released from prison, Mac and Charlie stage their own deaths.
- 7. Who Pooped the Bed? Oct 9, 2008
- Dee leads the waitress and Artemis on a night out on the town.
- 8. Paddy's Pub: The Worst Bar in Philadelphia Oct 16, 2008
- A reporter calls Paddy's the worst bar in Philadelphia, so the gang kidnaps him to change his mind.
- 9. Dennis Reynolds: An Erotic Life Oct 23, 2008
- After finding Dennis' erotic memoir, Mac and Frank try to profit from the masterpiece.
- 10. Sweet Dee Has a Heart Attack Oct 30, 2008
- After Dee has a heart attack, she and Dennis try to live healthier lifestyles.
- 11. The Gang Cracks the Liberty Bell Nov 6, 2008
- The gang tells the Historical Society that Paddy's was responsible for cracking the Liberty Bell.
- 12. The Gang Gets Extreme: Home Makeover Edition Nov 13, 2008
- The gang decides to pay it forward and give an unlucky family an extreme home makeover.
- 13. The Nightman Cometh Nov 20, 2008
- With the help and support of his friends, Charlie stages a rock opera based on his song "Nightman."