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- OverviewSep 23, 1999-May 4, 200022 episodesEpisodes22. Have I Got a Deal for You May 4, 2000
- Hoyt Hospital Services wants to buy the hospital as an empty facility.
- 21. Everybody's Special at Chicago Hope Apr 27, 2000
- Heart-attack victim Hubert Miller deals with another patient fighting HMO bureaucracy.
- 20. Thoughts of You Apr 20, 2000
- Drs. Schutt and Simon perform an experimental brain surgery; Dr. McNeil is close to being fired.
- 19. Miller Time Apr 13, 2000
- An HMO acquires the hospital, and its owner is bent on cutting costs.
- 18. Devoted Attachment Apr 6, 2000
- Conjoined adult twins with pancreatic cancer refuse to be separated.
- 17. Cold Hearts Mar 30, 2000
- Drs. Schutt and Simon must induce a patient's hypothermia in order to operate.
- 16. Simon Sez Feb 24, 2000
- A mentally impaired couple discover that the hospital performed a hysterectomy years earlier.
- 15. Painful Cuts Feb 17, 2000
- Geiger attempts to perform surgery on his adopted daughter after she develops heart problems.
- 14. Gray Matters Feb 10, 2000
- A father must choose which of his two children will receive an organ donation.
- 13. Boys Will Be Girls Feb 3, 2000
- Dr. McNeil goes to court to help a teenage boy who has been forced to live as a girl.
- 12. Letting Go Jan 20, 2000
- A hepatitis scare forces Dr. Geiger to call for outside help.
- 11. Faith, Hope and Surgery Jan 13, 2000
- A Parkinson's patient teaches Dr. Simon a procedure that might save his life.
- 10. Hanlon's Choice Jan 6, 2000
- A woman refuses treatment because of religious beliefs; Dr. Hanlon fights to provide free treatment.
- 9. The Golden Hour Dec 9, 1999
- Drs. McNeil and Shutt become victims of a terrorist in an abandoned warehouse.
- 8. The Heart to Heart Nov 18, 1999
- Doctors perform an experimental surgery with guidance from a doctor in Sri Lanka.
- 7. White Rabbit Nov 11, 1999
- A mysterious plague attacks the hospital, causing multiple fatalities.
- 6. Upstairs, Downstairs Oct 28, 1999
- A widow asks doctors to impregnate her with her husband's sperm.
- 5. Humpty Dumpty Oct 21, 1999
- Dr. Cacaci is rushed to the emergency room after an apparent suicide attempt.
- 4. Vigilance and Care Oct 14, 1999
- Dr. McNeil puts the life of a young ballplayer in jeopardy while trying to save his arm.
- 3. Oh, What a Piece of Work Is Man Oct 7, 1999
- A newborn's life is in the hands of a heart surgeon who has Tourette syndrome.
- 2. You Gotta Have Heart Sep 30, 1999
- Geiger and Watters must choose between two patients to receive a heart.
- 1. Team Play Sep 23, 1999
- Priest wants injury kept secret; liposuction patient dies; Geiger can't operate on child.