Search results
researchgate.net
- The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic...
pubmed.ncbi.nlm.nih.gov › 33637672Metabolism pathways of arachidonic acids: mechanisms ... - PubMed
People also ask
How is arachidonic acid metabolized?
Where is arachidonic acid found?
How is arachidonic acid supplied to humans and mammals?
What is arachidonic acid (AA)?
How is arachidonic acid liberated from membrane phospholipids?
Feb 26, 2021 · Overview of the arachidonic acid (AA) metabolism pathways. Three major phospholipase enzymes (PLA2, PLC and PLD) are responsible for releasing AA from membrane-bound phospholipids by...
- Full Size Table
We would like to show you a description here but the site...
- Metrics
We would like to show you a description here but the site...
- Full Size Table
Mar 13, 2018 · The CYP 450 pathway involves two enzymes, CYP450 epoxygenase and CYP450 ω-hydroxylase giving rise to epoxyeicosatrienoic acid (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) respectively. Anandamide pathway comprises the FAAH (fatty acid amide hydrolase) to produce the endocannabinoid, anandamide [26] , [27] , [28] .
- Violette Said Hanna, Ebtisam Abdel Aziz Hafez
- 10.1016/j.jare.2018.03.005
- 2018
- J Adv Res. 2018 May; 11: 23-32.
In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis - double bonds; the first double bond is located at the sixth carbon from the omega end. Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids.
Feb 26, 2021 · The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further me ….
- Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Zheng Wen, Jiong Hu, Ingrid Fleming, Dao Wen ...
- 2021
Jun 6, 2021 · Arachidonic acid oxidation via the cyclooxygenase pathways has been detailed 4 − 7, 9 − 12 but remains obscure for many researchers. Cyclooxygenase 1 and 2 (COX-1 and -2) are also termed prostaglandin H synthase (PGHS)-1 and -2, because they direct synthesis of the prostaglandins.
- Hatem Tallima
- 10.1021/acsomega.1c01952
- 2021
- ACS Omega. 2021 Jun 22; 6(24): 15559-15563.
Aug 3, 2020 · Arachidonic acid can be liberated from membrane phospholipids via the action of phospholipase A2 or phospholipase C. The liberated arachidonic acid can then be metabolized via several enzymes to yield a vast array of vasoactive and immunomodulatory substances, termed “eicosanoids” (Fig. 1).
Tyrosine radical-catalyzed cyclooxygenase and peroxidase activities on arachidonic acid (ARA). (A) Generation of the tyrosyl radical by an intramolecular electron transfer undergone by heme-containing Compound I of cyclooxygenases (COXs). (B) Conversion of prochiral to chiral carbon by hydrogen abstraction.
