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Natalia Ivanova, PhD Associate Professor. Department of Genetics Center for Molecular Medicine 325 Riverbend Road Athens, GA 30602 Room 1212 phone: 706-542-6052 email: natalia.ivanova@uga.edu
- Ivanova, Natalia - Integrated Life Sciences - ils.uga.edu
Ivanova, Natalia. Associate Professor Biochemistry &...
- Natalia Ivanova | Biochemistry & Molecular Biology
Contact Information. natalia.ivanova@uga.edu. Office: CMM...
- Home - Ivanova Lab
The Ivanova Lab combines genetic, biochemical and...
- Research - Ivanova Lab
Our laboratory is interested in deciphering the gene...
- Ivanova, Natalia - Integrated Life Sciences - ils.uga.edu
The Ivanova Lab combines genetic, biochemical and bioinformatics approaches with embryonic stem cell models to gain insights into the molecular control of early development in humans.
Ivanova, Natalia. Associate Professor Biochemistry & Molecular Biology, Genetics. Transcriptional and epigenetic mechanisms regulating preimplantation development, pluripotency, differentiation and cellular reprogramming in humans.
- Global Gene Regulatory Network For Pluripotency Maintenance in Humans
- Mechanisms of Targeting and Repression by The Non-Canonical PRC1 Complexes
- Chromatin Remodeling During Cellular Reprogramming and Differentiation
- Derivation of Human Induced Trophoblast Stem Cells
While naïve pluripotency has been extensively studied in mice, primed pluripotency in humans remains poorly defined. We have begun systems level analyses of human ESC pluripotency by conducting whole-genome shRNA screens. Through these analyses we have compiled comprehensive lists of transcription and epigenetic factors whose depletion impairs plur...
Polycomb group proteins regulate self-renewal and differentiation in many stem cell systems. When assembled into two canonical complexes, (c)PRC1 and PRC2, they sequentially deposit H3K27me3 and H2AK119ub histone marks and establish repressive chromatin, known as Polycomb domains. Non-canonical (nc)PRC1 complexes which retain RNF2 E3-ubiquitin liga...
As somatic cells are converted into iPSCs, their chromatin is remodeled to a pluripotent configuration with unique euchromatin-to-heterochromatin ratio, DNA methylation patterns and enhancer/promoter status. The molecular machinery underlying this process is largely unknown. We have recently shown that ESC-specific factors Dppa2 and Dppa4 play a ke...
The trophectoderm (TE) is an extraembryonic tissue that supplies instructive signals required for embryo patterning during gastrulation and gives rise to the placenta, an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, waste elimination, gas exchange and thermoregulation via the mother’s blood supply. In mice,...
Contact Information. natalia.ivanova@uga.edu. Office: CMM 1212. Phone Number: 706-542-6052.
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Z Wang, E Oron, B Nelson, S Razis, N Ivanova. Cell stem cell 10 (4), 440-454. , 2012.
Natalia Ivanova's 21 research works with 1,333 citations and 5,552 reads, including: 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development.
