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In his most famous experiment, Loewi took fluid from one frog heart and applied it to another, slowing the second heart and showing that synaptic signaling used chemical messengers. The Nobel Prize diploma of Otto Loewi, housed at the University of Graz
In that famous experiment, Loewi placed two beating frog hearts, each in its own perfusion chamber – one preparation had the vagus nerve intact, while the other was denervated. Next, he stimulated the vagus nerve supplying the first heart, causing it to beat more slowly – a phenomenon that was already well known at the time.
- Alli N McCoy, Siang Yong Tan
- 10.11622/smedj.2014002
- 2014
- Singapore Med J. 2014 Jan; 55(1): 3-4.
His neurological researches (1921–26) provided the first proof that chemicals were involved in the transmission of impulses from one nerve cell to another and from neuron to the responsive organ. He and his colleagues, by stimulating the nerves in the heart of a frog, slowed the heart’s rate of contraction.
- The Editors of Encyclopaedia Britannica
The foundation for Loewi's ideas. In the early 1900s, there was a great deal of discussion and experimentation designed to determine how communication across synapses occurred. In 1902, a young German researcher named Otto Loewi took a temporary position in a laboratory at University College London. There Loewi would meet several people who ...
May 27, 2021 · Abstract. One hundred years ago, a 4-page paper published in the Pflüger’s Archiv fűr die Gesamte Physiologie des Menschen und der Tiere dramatically changed our view on synaptic transmission. The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the ...
- Ricardo Borges, Antonio G. García
- 2021
INSPIRATION FOR EXPERIMENT. In 1921, Loewi devised a classical experiment, the outline of which came to him in several dreams. He awoke on the night of Easter Saturday in 1921 and wrote a few notes on a scrap of paper. To his horror, the next morning he could not decipher his own scrawl.
Oct 21, 2022 · Loewi’s critical experiment unambiguously pointed to chemical transmission . In his work, he credited several British scientists, including Thomas R. Elliott, William M. Bayliss (1860–1924), Reid Hunt (1870–1948), Walter E. Dixon (1871–1931), and Arthur Ewins (1882–1957), who had contributed previously to the concept that sympathetic ...
