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Mar 5, 2019 · A large study of 152 patients with metastatic uveal melanoma from one center and 102 from another center demonstrated that liver involvement, elevated LDH, and WHO performance status ≤1 were associated with worse prognosis, while those with longer disease-free interval from diagnosis of uveal melanoma to metastasis had a survival advantage .
- Table3 3
To describe treatment trends and outcomes of liver...
- Figure2a 2A
To describe treatment trends and outcomes of liver...
- PMC Free Article
Of 463 patients treated for metastatic uveal melanoma, 305...
- Long-Term Survivors With Metastatic Uveal Melanoma
The most common site of initial metastatic spread is the...
- Liver metastasis in uveal melanoma
Currently, there is no standard systemic treatment available...
- Table3 3
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Is uveal melanoma metastatic to the liver?
How long does uveal melanoma liver metastasis last?
What is the prognosis of uveal melanoma?
Uveal melanoma, the most common primary intraocular tumor, 1–4 has an associated approximate 40% risk of metastasizing to the liver within 10 years of diagnosis of the primary tumor. 1 Hepatic metastases, which occur in 95% of patients with metastatic uveal melanoma, 5 result in death in almost all cases. 6,7 It is important to understand the ...
- Hans E. Grossniklaus
- 10.1001/jamaophthalmol.2013.2547
- 2013
- 2013/04
Mar 5, 2020 · Patients with uveal melanoma metastatic to the liver who present without symptoms and receive local therapy as first-line treatment have longer progression-free survival (PFS) and overall survival (OS) than those who present with symptoms and receive other first-line therapies.
Feb 21, 2022 · Currently, there is no standard systemic treatment available for metastatic UM and once liver metastases have developed, prognosis is relatively poor. In order to prolong survival, close follow-up in all patients with UM is recommended for early detection and treatment.
Mar 1, 2022 · Further, several publicly available tools for prediction of metastatic probability have been developed, including The Liverpool Uveal Melanoma Prognosticator Online (LUMPO) and Predicting...
Jan 4, 2023 · Treatment of primary uveal melanoma with radiotherapy, enucleation or other modalities achieves local control in more than 90% of patients, although 40% or more ultimately develop distant...
there are 2 main growth patterns of metastatic uveal melanoma to the liver, although both may be present. In the infiltrating pattern, micrometastases arise in the sinusoidal spaces. In the nodular pattern, micrometastases arise in the area of the portal triad.
