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Learn about the genetic immunodeficiency condition that affects IgA antibodies and increases the risk of celiac disease. Find out how to test for celiac disease accurately in people with IgA deficiency and what to do if you have both conditions.
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How common is IgA deficiency in celiac disease?
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Can selective IgA deficiency cause autoimmune diseases?
Immunoglobulin A (IgA) deficiency is 10 to 15 times more common in patients with celiac disease (CD) than in healthy subjects. Serological tests have become the preferred methods of diagnosing CD in both symptomatic and asymptomatic patients.
- V. Kumar, M. Jarzabek-Chorzelska, J. Sulej, Krystyna Karnewska, T. Farrell, S. Jablonska
- 10.1128/CDLI.9.6.1295-1300.2002
- 2002
- 2002/11
Aug 13, 2022 · In patients with known selective IgA deficiency, the IgG antibody levels for EMA, tTG and gliadin can be measured and are very effective in identifying patients with celiac disease. However, one generally does not know if the individual is IgA deficient.
Nov 23, 2019 · Selective IgA deficiency. Undetectable serum IgA, or less than 7 mg/dl when detected by nephelometry, in patients greater than 4 years old with normal levels of immunoglobulin G and M, normal vaccine response, and with the exclusion of secondary causes of hypogammaglobulinemia and T-cell defects.
- Samantha Swain, Samantha Swain, Carlo F Selmi, M. Eric Gershwin, Suzanne S Teuber, Suzanne S Teuber
- 2019
Mar 11, 2021 · In summary, celiac disease is mediated by tissue transglutaminase antibodies, typically of the IgA isoform. However, patients with celiac disease are at higher risk of having IgA deficiency. In this setting, IgA-based testing for celiac disease is often negative, complicating the clinical picture.
Jun 26, 2023 · Celiac disease is associated with IgG deficiency, the 8.1 haplotype, and the HLA-DQBO2 allele. Incidentally, patients with concurrent celiac disease and IgA deficiency have a greater incidence of other autoimmune illnesses when compared to individuals with celiac disease alone.
May 24, 2024 · Celiac disease. Inflammatory bowel disease. Common variable immunodeficiency, which is a lack of two or more types of immunoglobulins. Risk of reaction to blood products. People with selective IgA deficiency are at risk of reactions to blood transfusions or blood products.
