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  2. Help to Protect Against Pediatric Invasive Pneumococcal Disease. View Invasive Pneumococcal Disease Information About Babies at the Physician Site.

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  1. What Are the Possible Side Effects? Most people who get a pneumococcal vaccine do not have any serious problems with it. With any medicine, including vaccines, there is a chance of side effects. These are usually mild and go away on their own within a few days, but serious reactions are possible. Mild Problems PCVs

  2. Potential side effects of the pneumonia vaccine include injection site soreness, irritability, fever, loss of appetite, fatigue, and muscle aches. Pneumococcal disease is caused by common bacteria ( Streptococcus pneumoniae ).

    • On This Page
    • Pneumococcal Disease and How to Protect Against It
    • Pneumococcal Vaccine Side Effects
    • Common Side Effects of Pneumococcal Vaccine
    • Available Pneumococcal Vaccines
    • How CDC Monitors Vaccine Safety
    • A Closer Look at the Safety Data
    • More Resources
    • Related Scientific Articles
    • Related Links

    Child and Adult Immunization Schedules

    Get CDC’s official recommended immunization schedules for children, adolescents, and adults.

    Pneumococcal vaccines are very safe and effective at preventing pneumococcal disease. Vaccines, like any medicine, can have side effects. The most common side effects from pneumococcal vaccines are mild and last for 1 or 2 days.

    •Feeling drowsy

    •Loss of appetite

    •Sore or swollen arm from the shot

    •Fever

    •Headache

    Very rarely, severe (anaphylactic) allergic reactions may occur after vaccination.

    Pneumococcal conjugate vaccines (PCV13, PCV15, PCV20)

    •Prevnar13 (PCV13) [PDF – 43 pages]: The Food and Drug Administration (FDA) approved this vaccine in 2010 for use in children and in 2011 for use in adults. PCV13 replaced a previous pneumococcal vaccine, PCV7. PCV13 helps protect against 13 types of pneumococcal bacteria that cause the most severe illness among children and adults. •Vaxneuvance (PCV15) [PDF – 24 pages]: FDA approved this vaccine in 2021 for use in adults and in 2022 for use in children. PCV15 helps protect against 15 types of pneumococcal bacteria that commonly cause severe illness among adults. •Prevnar20 (PCV20) [PDF – 33 pages]: FDA approved this vaccine in 2023 for use in individuals ages 6 weeks and older. PCV20 helps protect against 20 types of pneumococcal bacteria that commonly cause severe illness among adults.

    Pneumococcal polysaccharide vaccine (PPSV23)

    •Pneumovax 23 (PPSV23) [PDF – 8 pages]: FDA approved this vaccine in 1983. It helps protect against serious infections caused by 23 types of pneumococcal bacteria. Top of Page

    CDC and FDA monitor the safety of vaccines after they are approved or authorized. If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public.

    CDC uses 3 systems to monitor vaccine safety:

    •The Vaccine Adverse Event Reporting System (VAERS): an early warning system, co-managed by CDC and FDA, to monitor for potential vaccine safety problems. Anyone can report possible vaccine side effects to VAERS.

    •The Vaccine Safety Datalink (VSD): a collaboration between CDC and 13 healthcare organizations that conducts vaccine safety monitoring and research.

    •A 2004 study found most VAERS reports in the first 2 years after licensure of 7-valent pneumococcal conjugate vaccine (PCV7) were minor known side effects.

    •Two large 2013 studies (Jackson et al; Jackson et al) conducted in the United States and Europe in adults ages 50 years and older compared PCV13 with PPSV23. Common adverse events reported with PCV13 were pain, redness, and swelling at the injection site; limited movement of the injected arm; tiredness; headache; chills; decreased appetite; generalized muscle pain; and joint pain.  Similar reactions were observed in adults who received PPSV23.

    Centers for Disease Control and Prevention. Licensure of 13-valent pneumococcal conjugate vaccine for adults aged 50 years and older. MMWR. 2012 Jun 1;61(21):394-5.

    Hak E, Grobbee DE, Sanders EA, et al. Rationale and design of CAPITA: A RCT of 13-valent conjugated pneumococcal vaccine efficacy among older adults. Neth J Med. 2008;66:378–83.

    Jackson LA, Gurtman A, van Cleeff M, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine. 2013;31:3577–84.

    Jackson LA, Gurtman A, Rice K, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine. Vaccine. 2013;31:3585–93.

    Kobayashi M, Farrar JL, Gierke R, Britton A, Childs L, Leidner AJ, Campos-Outcalt D, Morgan RL, Long SS, Talbot HK, Poehling KA, Pilishvili T. Use of 15-Valent Pneumococcal Conjugate Vaccine and 20-Valent Pneumococcal Conjugate Vaccine Among U.S. Adults: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022. MMWR. 2022;71(4);109–117.

    Kobayashi M, Farrar JL, Gierke R, Leidner AJ, Campos-Outcalt D, Morgan RL, Long SS, Poehling KA, Cohen AL. Use of 15-Valent Pneumococcal Conjugate Vaccine Among U.S. Children: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2022. MMWR. 2022;71(37);1174–1181.

  3. Nov 29, 2023 · Pneumococcal Vaccine Side Effects . Like any other medication or vaccine, there may be side effects from the pneumococcal vaccine. If you do get side effects, they are typically very mild and only last a day or two.

  4. Nov 19, 2021 · Depending on the vaccine that’s administered, side effects can vary, but the most common side effects of the pneumococcal vaccine include: redness or pain at the site of the shot....

  5. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

  6. Feb 6, 2024 · Pneumococcal vaccines are safe, but side effects can occur. Adults receiving pneumococcal conjugate and polysaccharide vaccines have reported mild side effects such as: Fatigue; Headache; Mild fever and chills; Muscle pain; Redness, pain, and swelling at the injection site; Life-threatening allergic reactions from either type of vaccine are rare.

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