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Mar 21, 2019 · Sepsis is a medical emergency that describes the body’s systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death.
- Sepsis—Pathophysiology and Therapeutic Concepts - PMC
Sepsis is a life-threatening condition and a global disease...
- Bacterial Sepsis - StatPearls - NCBI Bookshelf
Review the pathophysiology of bacterial sepsis. Describe the...
- Sepsis - National Institute of General Medical Sciences
Sepsis is a person’s overwhelming or impaired whole-body...
- Sepsis—Pathophysiology and Therapeutic Concepts - PMC
May 14, 2021 · Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology.
- Dominik Jarczak, Stefan Kluge, Axel Nierhaus
- 10.3389/fmed.2021.628302
- 2021
- Front Med (Lausanne). 2021; 8: 628302.
- Key Facts
- Overview
- Who Is at Risk?
- Signs and Symptoms
- Prevention
- Treatment
- Sustainable Development Goals
- Who Response
Sepsis is one of the most frequent causes of death worldwide, but there are challenges in collecting reliable data at the population level (1).From data published in 2020, there were 48.9 million cases and 11 million sepsis-related deaths worldwide, representing 20% of all global deaths (2).Almost half (20 million) of all estimated sepsis casesworldwide occurred in children under 5 years of age.For every 1000 hospitalized patients, an estimated 15 patients will develop sepsis as a complication of receiving health care.Sepsis is a life-threatening condition that happens when the body’s immune system has an extreme response to an infection, causing organ dysfunction (4). The body’s reaction causes damage to its own tissues and organs and it can lead to shock, multiple organ failure and sometimes death, especially if not recognized early and treated promptly. Sepsi...
Anyone affected by an infection, severe injury, or serious non-communicable disease can progress to sepsis but vulnerable populations are at higher risk (6,7) including: 1. older persons 2. pregnant or recently pregnant women 3. neonates 4. hospitalized patients 5. patients in intensive care units 6. people with weakened immune systems (for example...
Sepsis is a medical emergency. It can cause different signs and symptoms at different times. People who think they may have sepsis should seek medical care right away. Common signs and symptoms include: 1. fever or low temperature and shivering 2. confusion 3. difficulty breathing 4. clammy and sweaty skin 5. extreme body pain or discomfort 6. high...
Sepsis can be prevented by treating infections early and through good hygiene at home and in healthcare settings. The best way to reduce the risk of sepsis is to avoid infections. Steps include: 1. good personal hygiene, like washing hands and preparing food safely 2. avoiding unclean water or unsanitary toilets 3. getting vaccines recommended by l...
Treatment for sepsis is most effective when started early. Health workers watch for concerning signs and use tests to diagnose sepsis. They will then work to find the source of the infection. Early use of antimicrobials to treat bacteria, parasites, fungus or viruses is essential to improve outcomes from sepsis. Low blood pressure is treated by int...
Sepsis is a significant cause of maternal, neonatal and child mortality. Consequently, combating sepsis will contribute to achievement of Sustainable Development Goals (SDGs) targets 3.8 on quality of care, and 3.1 and 3.2 by improving mortality rates in these vulnerable populations. Sepsis can also ultimately lead to death in patients affected by ...
To combat this important global health threat, WHO responded with a WHO Secretariat Report and, in May 2017, the Seventieth World Health Assembly adopted Resolution WHA70.7 on improving the prevention, diagnosis and clinical management of sepsis. The key pillars of Resolution WHA70.7 are to: 1. develop WHO guidelines on the clinical management of s...
Feb 10, 2023 · Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock. This is a dramatic drop in blood pressure that can damage the lungs, kidneys, liver and other organs.
Jan 18, 2024 · INTRODUCTION. The normal host response to infection is a complex process that localizes and controls bacterial invasion, while initiating the repair of injured tissue. It involves the activation of circulating and fixed phagocytic cells, as well as the generation of proinflammatory and anti-inflammatory mediators.
May 21, 2023 · Review the pathophysiology of bacterial sepsis. Describe the typical lab findings in bacterial sepsis. Summarize the components of the acute sepsis bundle and the components of the sepsis management bundle used in the evaluation and treatment of patients with sepsis.
Jan 3, 2024 · Sepsis is a person’s overwhelming or impaired whole-body immune response to an insult —an infection or an injury to the body, or something else that provokes such a response. Sepsis occurs unpredictably and can progress rapidly. In the worst cases, blood pressure drops, the heart weakens, and the patient spirals toward septic shock.
