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  1. The water intrusion test (WIT) is widely used in the pharmaceutical industry to test the integrity of vent filtration for holding tanks and bioreactors, autoclave and lyophilizer vent filters. The purpose of this document is to present

  2. Perform the integrity test in a lower surface tension reference fluid to assess filter wettability changes independent of filter integrity. If the filter fails using the reference fluid, the filter fails the test.

  3. Nov 10, 2022 · A water intrusion test tests the volume of water that penetrates the membrane of a hydrophobic filter under a specific amount of pressure for a particular amount of time. The correct amount of pressure will penetrate the membrane but not get it wet.

  4. Nov 2, 2011 · The water intrusion test (WIT) for hydrophobic PTFE membrane cartridges enables in situ integrity testing without the interference of contaminative wetting media (e.g., alcohol) and obviates the need for downstream manipulation. WIT measures the decay rate of a pressure level imposed upon a hydrophobic membrane surrounded by water on the ...

  5. How the Water Intrusion Test Works Hydrophobic membranes, by definition, resist the flow of water through the membrane pores up to their “water intrusion pressure” (WIP). The WIP is directly related to the pore size and hydrophobicity of the filter membrane. require special proce When water is introduced to one side of the membrane at

  6. Due to occupational risks, environmental regulations, safety guidelines, and cost associated with handling these low surface tension solvents, water intrusion is becoming the method of choice for integrity testing of hydrophobic microbial rated filters for air or gas applications.

  7. How the Water Intrusion Test Works. Hydrophobic membranes, by definition, resist the flow of water through the membrane pores up to their “water intrusion pressure” (WIP). The WIP is directly related to the pore size and hydrophobicity of the filter membrane.

  8. Jun 24, 2015 · The Water Intrusion Test (WIT) is widely accepted within the industry, and overcomes the need to wet the filter membrane. This White Paper details several challenges associated with performing a successful WIT, including common reasons for “false failure” results.

  9. Jun 1, 2006 · In this context, an alternate, non-destructive method—the water intrusion test (WIT) 6 —is an established test. During the WIT test, or the very similar water flow test (WFT), the penetration of water into the hydrophobic membrane is measured under pressure and evaluated by comparing the results to a limit value.

  10. Dec 19, 2017 · The Water Intrusion Test is widely used in the pharmaceutical industry to test the integrity of tank, autoclave and lyophilizer vent filters. The purpose of this document is to present the collected best methods/practices to give filter end users the best possible chance of performing a successful WIT.

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