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  2. Oct 3, 2022 · The bivalent booster is the most recent version of the COVID-19 vaccine. It contains both the original vaccine strain [of the virus] and a strain derived from the BA.5 omicron variant, which is currently dominating here in the U.S., so that we can maximize protection against severe disease and potentially from infection. Who should be getting one?

    • Overview
    • What is a COVID-19 bivalent vaccine?
    • What’s the difference between the original COVID-19 vaccines and the bivalent vaccines?
    • How effective is the COVID-19 bivalent vaccine?
    • Who can get a COVID-19 bivalent vaccine?
    • Takeaway

    Bivalent COVID-19 vaccines contain two different components. One protects against the original strain of SARS-CoV-2, while the other protects against more recent variants.

    SARS-CoV-2, the virus that causes COVID-19, continues to evolve over time. This has led to the continued emergence of new viral variants.

    New variants differ significantly from the original strain of SARS-CoV-2 that was identified in 2019. For example, a 2022 review notes that, compared to the original strain of SARS-CoV-2, the Omicron variant carries at least 60 mutations.

    COVID-19 vaccines were developed based on the original strain of SARS-CoV-2. However, the continued evolution of the virus means that these original vaccines may not be as effective against newer variants.

    A COVID-19 bivalent vaccine has two different components. These provide two levels of protection.

    The first component protects against the original strain of SARS-CoV-2. This is the component that was present in the original COVID-19 vaccines. It aims to provide broad protection against SARS-CoV-2.

    The second component protects against more recent variants of SARS-CoV-2. This helps the COVID-19 vaccines keep pace with the continued evolution of the virus.

    The Food and Drug Administration (FDA) authorized two COVID-19 bivalent vaccines in the fall of 2022. These were mRNA vaccines produced by Pfizer-BioNTech and Moderna.

    The original COVID-19 vaccines were monovalent. This means that they contained one component. Meanwhile, as we discussed earlier, the bivalent vaccines contain two components.

    Overall, the side effects of the COVID-19 bivalent vaccine are similar to those of the original COVID-19 vaccine. Some of the most common side effects can include:

    •pain, swelling, or redness at the injection site

    •fatigue

    •fever, with or without chills

    •body aches and pains

    The COVID-19 bivalent vaccine is effective at protecting from serious illness and death due to COVID-19. However, the protection that it gives decreases in the weeks after it’s given.

    One study, published in the New England Journal of Medicine in May 2023, included data from roughly a little over 1.2 million people who had received a COVID-19 bivalent booster. Its key findings were:

    •The effectiveness against severe infection that resulted in hospitalization or death was:

    •67.4%, at 2 weeks after vaccination

    •47.5% after 4 weeks

    •44.3% after 10 weeks

    Currently, the CDC recommends that everyone ages 6 years and older receive a COVID-19 bivalent vaccine. This is regardless of whether you’ve previously had any of the original COVID-19 vaccines.

    Children under 6 years old who received the original COVID-19 vaccine can also get the COVID-19 bivalent vaccine. The number of doses used depends on the type of vaccine and number of doses they originally received, as well as age.

    Some individuals may get a second dose of the COVID-19 bivalent vaccine. This includes:

    •adults ages 65 years and older: recommended time frame is 4 or more months after their first dose of the COVID-19 bivalent vaccine

    COVID-19 bivalent vaccines contain two components. One protects against the original strain of SARS-CoV-2, while the other protects against more recent Omicron subvariants.

    The COVID-19 bivalent vaccine effectively protects against serious illness or death due to COVID-19, although protection wanes with time. Its side effects are similar to the original monovalent vaccine.

  3. May 14, 2024 · COVID-19. Stay Up to Date with COVID-19 Vaccines. Updated May 14, 2024. Español. Print. What You Need to Know. CDC recommends the 2023–2024 updated COVID-19 vaccinesPfizer-BioNTech, Moderna, or Novavaxto protect against serious illness from COVID-19.

  4. Oct 12, 2022 · "The bivalent booster vaccine is a new vaccine that provides protection against the original strain of COVID-19, as well as the two more recent variants BA.4 and BA.5," says Dr. Nipunie Rajapakse, a pediatric infectious diseases physician with the Mayo Clinic Children's Center.

  5. Jun 15, 2023 · Three COVID-19 vaccines are currently available for use in the United States and recommended by ACIP: 1) the bivalent mRNA Pfizer-BioNTech COVID-19 vaccine, 2) the bivalent mRNA Moderna COVID-19 vaccine, and 3) the monovalent adjuvanted, protein subunit-based Novavax COVID-19 vaccine.*

  6. Feb 7, 2023 · Bivalent booster vaccines against SARS-CoV-2 were 37% more effective than older booster shots at reducing the risk of severe COVID-19. The increased protection against hospitalization or death was seen regardless of age or whether people had previously received a different booster.

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  2. 65 And Older & Got A 2023-24 COVID-19 Shot? You May Be Eligible For An Additional Dose. Use The Vaccine Finder To Find COVID-19 Vax Locations Near You & Help Stay Protected.

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