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Apr 27, 2022 · Hypereosinophilic (hy-per-ee-o-SIN-o-phil-ik) syndrome (HES) is a group of blood disorders that occur when you have high numbers of eosinophils — white blood cells that play an important role in your immune system. Over time, the excess eosinophils enter various tissues, eventually damaging your organs. The most common targets are the skin ...
Hypereosinophilic syndrome is a rare medical condition caused by an overload of white blood cells called eosinophils. Left untreated, hypereosinophilic syndrome can be life-threatening. Fortunately, prompt diagnosis and treatment mean more than 80% of those diagnosed with hypereosinophilic syndrome are alive five years after diagnosis.
Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow.
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What is hypereosinophilic syndrome (HES)?
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Dec 9, 2022 · Eosinophilia, defined as an absolute eosinophil count (AEC) >0.45 × 10 9 /L, is quite common, occurring in 1% to 2% of the general population. 1 In contrast, hypereosinophilia (HE; AEC ≥1.5 × 10 9 /L) is extremely rare, with an estimated incidence of 0.315 to 6.3 per 100 000 in the United States. 2 The potential etiologies of eosinophilia (including HE) are varied and include allergic ...
Apr 27, 2022 · Treatment for hypereosinophilic syndrome is aimed at reducing your eosinophil count to prevent tissue damage, especially to your heart. Specific treatment depends on your symptoms, the severity of your condition and the cause of your HES. If you have no symptoms and your eosinophil count is low enough, you might require no treatment other than ...
Jan 11, 2024 · Hypereosinophilic syndrome (HES) encompasses a rare and complex group of heterogeneous disorders characterized by persistent and substantial elevations in eosinophil levels and mediators leading to tissue infiltration and damage.[1] Eosinophilopoiesis plays a vital role in the pro-inflammatory processes of multiple diseases.
Hypereosinophilic syndrome is peripheral blood eosinophilia (> 1500/mcL [> 1.5 × 109/L]) not caused by parasitic, allergic, or other secondary causes of eosinophilia, that has persisted ≥ 6 months and caused organ damage or dysfunction. Hypereosinophilic syndrome appears to be a manifestation of a number of hematopoietic disorders, some of ...
