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Serotonin syndrome is a serious drug reaction. It is caused by medications that build up high levels of serotonin in the body.
Serotonin is a chemical that the body produces naturally. It's needed for the nerve cells and brain to function. But too much serotonin causes signs and symptoms that can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures). Severe serotonin syndrome can cause death if not treated....
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Serotonin syndrome symptoms usually occur within several hours of taking a new drug or increasing the dose of a drug you're already taking.
Signs and symptoms include:
Severe serotonin syndrome can be life-threatening. Signs include:
Excessive accumulation of serotonin in the body creates the symptoms of serotonin syndrome.
Typically, nerve cells in the brain and spinal cord produce serotonin that helps regulate attention, behavior and body temperature.
Other nerve cells in the body, primarily in the intestines, also produce serotonin. Serotonin plays a role in regulating the digestive process, blood flow and breathing.
Although it's possible that taking just one drug that incre...
Treatment of serotonin syndrome depends on the severity of your symptoms.
Depending on your symptoms, you may receive the following treatments:
Milder forms of serotonin syndrome usually go away within 24 to 72 hours of stopping medications that increase serotonin. You may need to take medications to block the effects of serotonin already in your system.
However, symptoms of serotonin syndrome caused by some anti...
Taking more than one serotonin-related medication or increasing your dose of a serotonin-related medication increases your risk of serotonin syndrome. Know what medications you take and share a complete list of your medications with your doctor or pharmacist.
Be sure to talk to your doctor if you or a family member has experienced symptoms after taking a medication.
Also talk to your doctor about possible risks. Don't stop taking any medications on your own. If your doctor prescribes...
For informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment.
© Mayo Clinic
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