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How is acquired aplastic anemia treated?
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Jul 17, 2023 · Explain the treatment and management options available for aplastic anemia. Summarize interprofessional team strategies for enhancing care coordination and communication to advance treatment of aplastic anemia and improve outcomes.
- Approach to the diagnosis
Establishing a diagnosis of aplastic anemia (AA) can be...
- Diagnosis and Treatment
Approach to diagnosis and treatment of acquired aplastic...
- Approach to the diagnosis
To diagnose AA, there must be at least two of the following, haemoglobin concentration (Hb) <100 g/L, platelet count <50 × 109/L and neutrophil count <1.5 × 109/L. Reticulocyte count is useful in delineating the severity of AA. The majority (70%–80%) of cases are idiopathic.
Oct 1, 2021 · This topic reviews the treatment and prognosis of AA in adults. For adults, the evaluation of pancytopenia; pathogenesis, clinical manifestations, and diagnosis of AA; and hematopoietic cell transplantation for AA are discussed separately. (See "Approach to the adult with pancytopenia" and "Aplastic anemia: Pathogenesis, clinical manifestations ...
Jun 6, 2021 · Establishing a diagnosis of aplastic anemia (AA) can be challenging, but it is absolutely critical to appropriate management, especially differentiating between acquired and inherited forms of the disease.
- Amy E. DeZern, Jane E. Churpek
- 10.1182/bloodadvances.2021004345
- 2021
- Blood Adv. 2021 Jun 22; 5(12): 2660-2671.
Mar 16, 2017 · Treatment strategy in patients with acquired aplastic anemia. Patients are stratified according to whether or not they have an HLA-identical sibling. In young patients (<40 years) with a matched donor, allogeneic BMT is first-line therapy.
- Andrea Bacigalupo
- 2017
The standard first-line treatment for newly diagnosed acquired severe/very severe AA patients is horse anti-thymocyte globulin and ciclosporin-based immunosuppressive therapy (IST) with eltrombopag or allogeneic haemopoietic stem cell transplant (HSCT) from a matched sibling donor.
Nov 11, 2017 · Approach to diagnosis and treatment of acquired aplastic anemia. Initial screening evaluation of a patient with aplastic anemia is required to document pancytopenia with a hypocellular marrow, followed by testing to exclude alternative diagnoses.
