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Dr. Bruce Ames is devoted to identifying strategies that combat degenerative disease and reverse aging processes. Best known for his groundbreaking research on mitochondria, the UC Berkeley professor emeritus discusses his innovative Triage Theory of Aging.
The triage theory predicts that more moderate levels of deficiency could be causing insidious changes that, over time, culminate in age-‐associated chronic disease.
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What is the triage theory of aging?
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Aug 22, 2012 · I posited, and have buttressed, "triage theory" (1,2): metabolism responds to moderate deficiency of an essential vitamin or mineral (V/M) so that the scarce V/M is preferentially retained by V/M-dependent proteins necessary for short-term survival and reproduction.
Oct 15, 2018 · The triage theory provides a unifying rationale for why modest V/M deficiencies—insufficient to elicit overt symptoms of severe deficiency—might contribute significantly to the aging process and the diseases of aging.
Dr. Bruce Ames in his 2006 paper, where he proposed the Triage Theory, talks about how old rats create more oxidative by-products (waste material) and decreased function. But when you feed acetyl carnitine (ACL) and lipoic acid (LA) to old rats, they get most of their mitochondrial function back.
Strong support for triage theory comes from our analyses of published data on proteins dependent on vitamin K (3) and on selenium (4). Both of these V/M have built into metabolism a triage-like trade-off between short-term survival and long-term health; each uses a different mechanism to accomplish this end.
