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- The Frank–Starling Law mandates that the heart is able to match cardiac ejection to the dynamic changes occurring in ventricular filling and thereby regulates ventricular contraction and ejection.
www.ncbi.nlm.nih.gov › pmc › articlesHistorical perspective on heart function: the Frank–Starling Law
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Nov 19, 2015 · Abstract. More than a century of research on the Frank–Starling Law has significantly advanced our knowledge about the working heart. The Frank–Starling Law mandates that the heart is able to match cardiac ejection to the dynamic changes occurring in ventricular filling and thereby regulates ventricular contraction and ejection.
- Vasco Sequeira, Jolanda van der Velden
- 2015
As the Frank-Starling Law is a vital event for the healthy heart, it is of utmost importance to understand its mechanical basis in order to optimize and organize therapeutic strategies to rescue the failing human heart. The present review is a historic perspective on cardiac muscle function.
- Vasco Sequeira, Jolanda van der Velden
- 2015
The Frank–Starling law of the heart indicates that the increased filling pressure of the right heart results in increased cardiac output. Any increase in output of the right heart is quickly communicated to the left heart as an increased filling pressure.
Dec 3, 2002 · Starling’s Law of the Heart is a manifestation of the length-tension relationship seen in skeletal muscle, which was well known to physiologists during the second half of the 19th century.
- Arnold M. Katz
- 2002
Oct 10, 2022 · It is broadly received that Starling's Law, or now more commonly the Frank–Starling Law of the Heart, is the observation describing the intrinsic mechanical property of the heart whereby muscle force increases with initial length, which goes pari passu with ventricular output increasing with venous pressure. The latter relation is referred as ...
- 10.1113/JP283632
- 2022/10/10
- J Physiol. 2022 Oct 1; 600(19): 4265-4285.
Feb 11, 2021 · Frank-Starling law of the heart. Frank-Starling relationship is the observation that ventricular stroke volume increases as preload (end-diastolic pressure) increases, a beat-to-beat adjustment to maintain cardiac output. It is a positive relationship between end-diastolic volume and ejection volume (de Tombe et al. 2010; Farman et al. 2011 ).
Dec 15, 2007 · Mechanisms of the Frank-Starling Law of the Heart: The Beat Goes On. Cellular and molecular mechanisms remain elusive nearly a century after Frank, Starling, and colleagues demonstrated that an increase in ventricular filling (sarcomere length) promotes an increase in developed pressure (tension).
