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1. academic.oup.com › ecco-jcc › articleHead-to-head Comparative Studies: Challenges and ...

   academic.oup.com › ecco-jcc › article

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   Oct 13, 2016 · Head-to-head superiority trials constitute a true challenge for investigators because they are eagerly awaited by patients and the regulatory authorities. If these studies are methodologically rigorous [particularly with regard to selection criteria], this type of study could profoundly change our routine clinical practice.

   • Author: Laurent Peyrin-Biroulet, Anthony Lopez, William Sandborn

   • Publish Year: 2016

2. pubmed.ncbi.nlm.nih.gov › 22205018Head to head comparisons as an alternative to ... - PubMed

   pubmed.ncbi.nlm.nih.gov › 22205018

   Abstract. Head to head trials have been proposed as an alternative to the ethical and methodological concerns related to placebo-controlled trials. While those studies may be particularly informative from the clinical and cost-effectiveness point-of-view, avoiding placebo poses several regulatory concerns: for superiority designs, the choice of ...

   • Author: Eduara Vieta, Nuria Cruz

   • Publish Year: 2012

3. www.ncbi.nlm.nih.gov › pmc › articlesIndirect Comparisons and Network Meta-Analyses - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 20, 2015 · Indirect comparisons and network meta-analyses make it possible to estimate effects in order to compare different interventions in systematic reviews even if there are no head-to-head trials of them. They also allow for simultaneous analysis of networks containing more than two interventions.

   • Author: Corinna Kiefer, Sibylle Sturtz, Ralf Bender
   • DOI: 10.3238/arztebl.2015.0803

   • Publish Year: 2015
   • Published: 2015/11

4. healthjournalism.org › glossary-terms › head-to-headHead-to-head trial | Association of Health Care Journalists

   healthjournalism.org › glossary-terms › head-to-head

   In a head-to-head clinical trial, researchers are not comparing an intervention against a placebo or sham control but instead are comparing two different interventions that have each previously been shown effective. The goal is to identify which intervention is safer and/or more effective at treating the same condition.

5. www.cytel.com › hubfs › H2H Weinar 2 Slides CVDHead-to-head Comparisons using Real- World Data

   www.cytel.com › hubfs › H2H Weinar 2 Slides CVD

   Overview. Patients with type 2 diabetes on metformin often fail to achieve/maintain glycemic control and require second-line therapy. >6 classes of anti-diabetic drugs have been approved for use. A head-to-head comparison of effectiveness, safety is lacking.

6. www.researchgate.net › publication › 308570705_HeadHead-to-head Comparative Studies: Challenges and Opportunities?

   www.researchgate.net › publication › 308570705_Head

   Sep 22, 2016 · PDF | Therapeutic advances need a high level of evidence, such as that provided by placebo-controlled randomised clinical trials. These trials are also... | Find, read and cite all the research ...

7. People also ask

   What is a head-to-head trial?

   • Head-to-head trials designed and powered to enable formal comparisons are the gold standard in comparative research. Indeed, these trials are requested by some health authorities for evaluating the positioning of new treatments in IBD, as well as helping prescribing physicians to select the most appropriate treatment options for their patients.

   Head-to-head trials in inflammatory bowel disease: past, present and future - Nature

   www.nature.com/articles/s41575-020-0293-9

   See all results for this question

   Can a head-to-head trial compare two interventions?

   • If there is no evidence available from head-to-head trials comparing two interventions, but trials comparing each of the interventions of interest with the same comparator (e.g. a placebo) have been conducted, the method of adjusted indirect comparison as described by Bucher et al. ( 13) is appropriate.

   Indirect Comparisons and Network Meta-Analyses - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4678383/

   See all results for this question

   What is a head-to-head superiority study?

   • Head-to-head superiority trials constitute a true challenge for investigators because they are eagerly awaited by patients and the regulatory authorities. If these studies are methodologically rigorous [particularly with regard to selection criteria], this type of study could profoundly change our routine clinical practice.

   Head-to-head Comparative Studies: Challenges and Opportunities?

   academic.oup.com/ecco-jcc/article/11/suppl_2/S567/2631863

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   Are head-to-head trials a safe alternative to placebo-controlled trials?

   • Head to head trials have been proposed as an alternative to the ethical and methodological concerns related to placebo-controlled trials. While those studies may be particularly informative from the clinical and cost-effectiveness point-of-view, avoiding placebo poses several regulatory concerns: fo …

   Head to head comparisons as an alternative to placebo ... - PubMed

   pubmed.ncbi.nlm.nih.gov/22205018/

   See all results for this question

8. www.nature.com › articles › s41575/020/0293-9Head-to-head trials in inflammatory bowel disease: past ...

   www.nature.com › articles › s41575/020/0293-9

   Apr 17, 2020 · Abstract. With the increase in the number of novel drugs for inflammatory bowel disease (IBD), comparing therapeutic options or strategies has become a key challenge in IBD trials....