Search results
HEAD-TO-HEAD meaning: 1. involving a direct competition between two people or teams: 2. involving a direct competition…. Learn more.
HEAD-TO-HEAD definition: 1. involving a direct competition between two people or teams: 2. involving a direct competition…. Learn more.
Head-to-head definition: in direct confrontation, opposition, or competition. See examples of HEAD-TO-HEAD used in a sentence.
- Introduction
- Conclusion
- Live Discussion
- Conflict of Interest
- Acknowledgements
Therapeutic advances need a high level of evidence, such as that provided by placebo-controlled randomised clinical trials. These trials are also required for marketing authorisation by the health authorities. However, in the development of several novel drugs, the performance of a placebo-controlled trial may be unethical due to a potential loss o...
Over the past few years, the gold-standard paradigm for evaluating and approving new therapeutics has changed. Non-inferiority trials are increasingly frequent, and the regulatory authorities have validated this type of study for the approval of new drugs [and especially biosimilars]. However, these studies have specific methodological and statisti...
Laurent Peyrin-Biroulet:
So maybe, Anne, we could have first your feedback about your interpretation of the REACT trial, because you know very well the story and primary point 1 year and then analysing at 2 years; it was positive, so what did we learn from the REACT trial in terms of head-to-head strategy?
Anne Robinson:
We actually funded that trial, that was an IIS study, so it was not proposed by us. It was not intended for labelling and that’s one of the challenges in, to address Jean-Fred’s earlier comment, about getting funding. It is somewhat more difficult in industry to get funding for trials where it’s not easy to quantify what the potential financial outcome will be. That was a significant hurdle for us. For both REACT 1 and REACT 2. Those are large studies that are on par with a phase 3 study in t...
Dr. Elmer Schabel (BfArm, Bonn, Germany and European Medicines Agency, London, UK):
Well, we had actually the exact discussion about placebo: is it ethically still acceptable and what is it needed for in clinical trials? It is the exact discussion of last years.
LPB: consulting fees from Merck, Abbott, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillots, Vifor, Shire, Therakos, Pharmacosmos, Pilège, BMS, UCB-pharma, Hospira, Celltrion, Takeda, Boerhinger-Ingelhei;. lecture fees from Merck, Abbott, Janssen, Ferring, Norgine, Tillots, Vifor, Therakos, HAC-pharma. AL: lecture fees from Abbvie. WS: perso...
All authors have made substantial contributions to drafting the article or revising it critically for important intellectual content, and approved the final version to be submitted. LPB and AL drafted the article and JCF and WS reviewed and corrected the content.
- Laurent Peyrin-Biroulet, Anthony Lopez, William Sandborn
- 2016
Definition of head-to-head adjective in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.
head–to–head. 1 ENTRIES FOUND: head–to–head (adverb) head–to–head adverb. Britannica Dictionary definition of HEAD–TO–HEAD. : in a direct competition or contest. The two teams will compete head-to-head for the championship. He'll go head-to-head with his toughest opponent in the upcoming debate.
People also ask
What does head-to-head mean?
What is a head-to-head approach?
What is head-to-head development?
What is a head-to-head superiority study?
May 24, 2017 · Our Solution: Head-to-Head. At Two Sigma, we’ve addressed the dependency and reuse problem by adhering to a “head-to-head” development process that combines several industry practices: Trunk-Based Development : Developers make most changes to each component within a single (trunk) branch. Production software ships from release branches.
