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Is pancytopenia idiopathic?
What does pancytopenia mean?
Is pancytopenia life threatening?
Feb 21, 2023 · Pancytopenia is not a disease in itself. Rather, it is an occurrence brought on by infections, autoimmune disorders, genetic factors, nutritional deficiencies, or certain types of cancer. The...
- Sherri Gordon
Jan 16, 2021 · Left untreated, pancytopenia is extremely serious and can lead to life-threatening bleeding and infections. In younger patients, treatments such as bone marrow transplant and blood transfusion are generally successful at treating pancytopenia, but complications tend to be more severe in the elderly.
Presentation. Pancytopenia has a very broad differential diagnosis. Fortunately, for a 76-year-old woman with abnormal blood counts, the cause was easily treated. The patient presented to the Emergency Department of our hospital after 10 days of fever, malaise, and anorexia. Daily fevers had been as high as 38.9°C (102°F).
- Anubodh Varshney, Ebrahim Barkoudah, Ebrahim Barkoudah
- 2018
- I. Problem/Condition
- A. What Is The Differential Diagnosis For This Problem?
- B. Describe A Diagnostic approach/method to The Patient with This Problem
- Historical Information Important in The Diagnosis of This Problem
- C. Criteria For Diagnosing Each Diagnosis in The Methods Above
- A. Management of Clinical Problem Pancytopenia
- B. Common Pitfalls and Side-Effects of Management of This Clinical Problem
- VII. What's The Evidence?
Pancytopenia is defined by low counts of all cell lines including leukocytes, erythrocytes, and platelets.
Given pancytopenia is a sign, not a particular diagnosis, it has a broad differential diagnosis. These diagnoses can be broadly divided between inherited and acquired causes, but for providers who focus on adults, inherited causes will be a rare finding as most of these cases present in childhood. The categories of diseases and conditions that can ...
Pancytopenia is defined by a CBC showing low numbers of platelets, white blood cells, and red blood cells. A full differential should typically be included to exclude the presence of grossly abnormal forms given the presence of acute leukemia on the differential as a catastrophic illness that requires prompt treatment. Assessment of red blood cell ...
For immediate management, the most important historical questions to ask are about symptoms of the cytopenias and thus assessing the need to directly address them with transfusions. For example, questions about chest pain, shortness of breath, light headedness, or fainting can help determine the need for red blood cell transfusions. Similarly, the ...
Fanconi anemia was historically tested for by exposing chromosomes to chemotherapy and assessing for excessive structural damage, but it can now be assessed by genetic testing. Dyskeratosis similarly can be checked for by genetic testing. Diagnosing malignant or neoplastic causes may be simplified if there are circulating lymphoblasts or myeloblast...
Initial management of the pancytopenic patient must focus on stabilizing the physiologic derangements due to the lack of important blood cell components. Most treatments for the underlying disorders will not take effect for some time and thus, immediate stabilization is important. Immediate management of anemia will typically focus on transfusion. ...
Side effects of transfusion are covered elsewhere and consist largely of acute hemolytic reactions and non-hemolytic febrile reactions. TRALI (transfusion associated acute lung injury) is particularly associated with platelet transfusions.
Freifeld, AG, Bow, EJ. “Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America”. Clinical Infectious Diseases. vol. 52. 2011. pp. 56-93. Greinacher, A, Selleng, K. “Thrombocytopenia in the Intensive Care Unit Patient”. Hematology / The Education ...
Nov 16, 2023 · Pancytopenia is a reduction in the number of red blood cells, white blood cells, and platelets in the peripheral blood below the lower limits of the age-adjusted normal range for healthy people. It is therefore the combination of anaemia, leukopenia, and thrombocytopenia. Pancytopenia may result ...
Aug 23, 2023 · Pancytopenia is a hematologic condition characterized by a decrease in all three peripheral blood cell lines. It is characterized by a hemoglobin value of less than 12 g/dL in women and 13 g/dL in men, platelets of less than 150,000 per mcL, and leukocytes of less than 4000 per ml (or absolute neutrophil count of less than 1800 per ml).
May 31, 2022 · Pancytopenia refers to decreases in all peripheral blood lineages and is considered to be present when all three cell lines are below the normal reference range. Pancytopenia can be associated with a multitude of disease states, some of which are life threatening.
