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Few reports have indicated the prognosis of dogs with myotonia associated with HAC. According to one study ( 11 ), the median survival time for dogs with pituitary-dependent HAC treated with trilostane was 662 d (range: 8 to 1971 d). In the present experience, dogs 1 and 2 survived for 2383 and 1902 d, respectively.
- Noriyuki Nagata, Masashi Yuki
- 2015
Aug 28, 2023 · Myotonia congenita (MC) is a genetic neuromuscular channelopathy that affects skeletal muscle fibers (striated muscle controlled by the somatic nervous system).[1] Myotonia, defined as a delay or failure of relaxation in contracted skeletal muscle, is considered to be the hallmark of the disease and results in prolonged rigidity resulting in stiffness, cramping, and muscle hypertrophy. MC is ...
- Elizabeth S. Bryan, Mahdi Alsaleem
- 2023/08/28
- University of Kansas
Atlantoaxial subluxation is most common in young toy or miniature breeds of dogs and is seen occasionally in large breed dogs as well. Signs usually develop within the first few years of life and consist of sudden or progressively worsening neck pain or difficulty moving. Signs can be mild or progress to paralysis of all 4 legs.
May 30, 2017 · Hyperkalemic periodic paralysis has 3 clinically distinct manifestations: (1) without myotonia, (2) with clinical or EMG myotonia, or (3) with paramyotonia congenita. In all 3 forms, the course of the paralytic attacks is the same, with episodes of flaccid muscle weakness. 53 , 54 Episodes typically begin in the first decade of life with ...
- M. Lowrie, L. Garosi
- 2017
May 11, 2018 · Non-dystrophic myotonias are a group of skeletal channelopathies including myotonia congenita and the sodium channel myotonias (paramyotonia congenita, potassium-aggravated myotonia, hyperkalemic periodic paralysis among others) caused by mutations affecting skeletal muscle ion channels (CLCN1, chloride voltage-gated channel 1; SCNA4, sodium voltage-gated channel alpha subunit 4) [1]. The non ...
Dec 20, 2005 · Myotonia Congenita in Miniature Schnauzers. 12/20/2005. Myotonia Congenita is a hereditary, skeletal muscle disorder. Mytonic puppies exhibit clinical signs at a few weeks of age because their muscles are hyperexcitable and contract easily. Affected dogs have prominent muscles in the shoulders and thighs and appear to have difficulty getting up ...
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What is the prognosis of myotonia in dogs?
What are the clinical signs and symptoms of myotonia congenita in dogs?
Do dogs have myotonia?
Myotonia congenita has been reported most frequently in the chow chow 19,25,26 and miniature schnauzer. 20,27,28 Individual dogs of various other breeds also have been described. 14-18,21 Clinical signs are similar in all reports. Although clinical signs are present at birth, muscle stiffness is more evident at the time pups begin to walk.
