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May 25, 2013 · INTRODUCTION. The autopsy, more correctly called necropsy, is a sequel and a completion of the study of disease after death. It consists of an examination of the corpses to determine the cause of death based on lesions found, in collaboration with clinical, radiological and laboratory data ().
- Mariana Costache, Monica Cirstoiu, Andreea Contolenco, Anca Mihaela Lazaroiu, Simion George, Maria S...
- Maedica (Bucur). 2014 Jun; 9(2): 183-188.
- 2014
- 2014/06
- Introduction and Basic Concepts
- Necropsy Personnel and Responsibilities
- Necropsy Data Collection
- Tissue Collection in Necropsy
- Missing Tissues
- Unscheduled Deaths
- Scenario A
- Scenario B
- Scheduled Deaths
- Use of Image Data in Necropsy/Pathology
10 A well-managed necropsy operation provides a system that assures that all protocol- required tissues and gross lesions are observed, recorded, and prop-erly fixed, for possible future histopathology evaluation. In regulated safety studies, a necropsy is performed to determine the possible cause of death and/ or to detect induced or coincidental ...
To successfully complete a necropsy, the following individuals are typically part of the necropsy team: study pathologist, study director, necropsy supervisor, senior pathology technician, pathology technical staff (animal transporters, blood collector/phlebotomist, dissector/prosector, weighing assistant), and quality assurance representative. Tab...
In preparation for the necropsy, the study protocol and a listing of animal num-bers (by animal group and sex) from the study need to be obtained and a pathology project number assigned. Necropsy pathology data can be recorded on individual necropsy sheets or captured into an electronic database. The pro-tocol-specific, species- specific, and sex-s...
There is a “best practices” section available on the website of the Society of Toxicologic Pathology (http://www.toxpath.org) and published enumerating the tissues that should be collected from Good Laboratory Practice (GLP)-quality repeated- dose toxicity studies that are supportive of the registration (Food and Drug Administration [FDA]) of new p...
Tissues or organs can be missing because of agenesis, maceration, or destruc-tion in the dissection process, or the tissue or organ is lost because of the activ-ity that occurs during the performance of the necropsy. In cases of agenesis and destruction of the tissue or organ, it is critical to thoroughly document the situ-ation. However, when a ti...
It cannot be emphasized enough that once animals are terminated, necropsy should immediately follow in order to avoid the effects of autolysis. If this is not possible, then refrigeration of the carcass is the next best option. Never should a carcass be frozen because freezing and the ultimate thawing will pro-duce significant tissue damage and com...
If an animal is found dead, it should be subjected to necropsy as soon as pos-sible using typical normal necropsy techniques. However, due to the presence of autolysis and cell death, the value of any biological samples collected will be questionable. These fluids can be collected if desired and saved or even analyzed but need to be appropriately m...
At times, an animal must be terminated in extremis as a result of a handling- induced injury (i.e., gavage error, significant skeletal injury [broken bone], and getting crushed between a cage and the cage rack). It is important to have a plan for unscheduled deaths so that the necropsy can be performed as close as possible to the time of death mini...
At times, highly detailed procedures regarding the execution of a necropsy will be delineated in the study protocol. However, when procedures are not speci-fied by the study protocol, animals should be terminated in numerical order, across the consecutive study groups to minimize the confounding effects of potential group- to- group variation and i...
The Society of Toxicologic Pathology has published a very useful reference on the use of image data in pathology (Tuomari et al. 2007). In general, images that are used for the generation of data are considered to be raw data. Alternatively, images that are not used to generate actual data are not consid-ered to be raw data. For example, an image ...
- Charles B. Spainhour, Shayne C. Gad
- 2020
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What is a necropsy / autopsy?
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Jan 18, 2010 · Necropsy or autopsy means “seeing for yourself”. It is a systematic examination of the body after death for the purpose of not only determining the cause of death, but to explain pathogenesis of the cause of death and identifying other pathology/pathologies associated with the case .
- Olugbenga A. Silas, Adeyi A. Adoga, Agabus N. Manasseh, Godwin O. Echejoh, Barnabas M. Mandong, Rahi...
- 3 (1.8%)
- 2009
- 163 (98.2%)
May 9, 2014 · A necropsy is performed to determine the possible cause of death and/or to detect induced or coincidental pathological alterations in tissues. The tools to perform a necropsy will vary not only by species, the type of dissection that is required, and personal preferences.
- Charles B. Spainhour
- 2014
Dec 1, 2016 · This study of 231 necropsy cases summarizes the various types of fatal CV and fatal non-CV disease, and the relation of heart weight to age, BMI, and cause of death at a single Texas tertiary hospital in a recent 3-year period.
- William C. Roberts, Vera S. Won, Anupama Vasudevan, Joseph M. Guileyardo
- 2016
Necropsy examinations can provide information as to the cause of death with greater accuracy than clinical diagnoses alone can. Further, in dogs it has been shown that clinical diagnoses were not consistently confirmed by necropsy, which often reveals alternate causes of death, or complex processes not understood without necropsy [10, 11].
pathologist’s opinion as to the cause of death may be included. In many cases, the cause of death may be obvious (e.g., a gunshot wound of the head), but in many cases, the findings are nebu-lous or multiple, and when appropriate, a differ-ential diagnosis should be discussed with a possible ranking of the probability of differing causes of ...
