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In his most famous experiment, Loewi took fluid from one frog heart and applied it to another, slowing the second heart and showing that synaptic signaling used chemical messengers. The Nobel Prize diploma of Otto Loewi, housed at the University of Graz
In a related experiment, Loewi showed that perfusate from a heart whose accelerator nerve was stimulated would cause a second heart to beat more quickly. He named the inhibitory factor ‘vagusstoff’, which is known today as acetylcholine.
- Alli N McCoy, Siang Yong Tan
- 10.11622/smedj.2014002
- 2014
- Singapore Med J. 2014 Jan; 55(1): 3-4.
In 1921, Loewi devised a classical experiment, the outline of which came to him in several dreams. He awoke on the night of Easter Saturday in 1921 and wrote a few notes on a scrap of paper. To his horror, the next morning he could not decipher his own scrawl.
May 30, 2024 · Otto Loewi was a German-born American physician and pharmacologist who, with Sir Henry Dale, received the Nobel Prize for Physiology or Medicine in 1936 for their discoveries relating to the chemical transmission of nerve impulses. After Loewi graduated in medicine (1896) from the German University.
- The Editors of Encyclopaedia Britannica
The foundation for Loewi's ideas. In the early 1900s, there was a great deal of discussion and experimentation designed to determine how communication across synapses occurred. In 1902, a young German researcher named Otto Loewi took a temporary position in a laboratory at University College London. There Loewi would meet several people who ...
May 27, 2021 · The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle.
Oct 1, 2018 · Answer: Otto Loewi conducted experiments on frog hearts that demonstrated that a chemical was released by nerves that can influence heart rate. Otto Loewi (1873-1961) was a German pharmacologist.
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