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  1. Apr 2, 2013 · Preparation and analytical characterization of 1‐ (1‐phenylcyclohexyl)piperidine (PCP) and 1‐ (1‐phenylcyclohexyl)pyrrolidine (PCPy) analogues - Wallach - 2014 - Drug Testing and Analysis - Wiley Online Library.

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  2. An attractive procedure from the standpoint of clandestine synthesis would be the reductive alkylation of PCA with acetone and aluminum amalgam to give the potent analog N-isopropyl phenylcyclohexylamine. The first method using PCA as an intermediate is Scheme IV. This route has received little attention among clandestine chemists, but has ...

  3. Abstract. Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay. In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with ...

    • Andrew Thurkauf, Brian De Costa, Shun Ichi Yamaguchi, Mariena V. Mattson, Arthur E. Jacobson, Kenner...
    • 1990
  4. thesis of 1-phenylcyclohexylamine. The compound prepared by the alternate route (method F) was identi- cal in all respects with the one obtained prepared from Method F aC6"I NCO - CxCeH5 "2 VI phenylcyclohexene. Recently, Cristol, et ul., re- ported the isolation of the amine as its benzoyl deriva- tive via a modified Ritter reaction.

    • 678KB
    • 6
  5. Abstract. 1-Phenylcyclohexylamine (PCA), an analog of phenyclidine (PCP) in which the piperidine ring is replaced by a primary amino group, and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline (PM-THIQ) were potent anticonvulsants in the mouse maximal electroshock (MES) seizure test (ED50 values, 7.0 and 14.3 mg ...

    • Michael A Rogawski, A. Thurkauf, S. I. Yamaguchi, K. C. Rice, A. E. Jacobson, M. V. Mattson
    • 1989
  6. Synthesis of deuterium‐labelled drugs of abuse for use as internal standards in quantification by selected ion monitoring. I. Methamphetamine; 2,5‐dimethoxy‐4‐methylamphetamine (DOM); phencyclidine (PCP); and methaqualone. Journal of Labelled Compounds and Radiopharmaceuticals 1976, 12 (1) , 69-78.

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  8. Sep 7, 2023 · New derivatives ( II-IV) were synthesized with changing of substituting on aromatic, cyclohexyl, and amine moieties of PCP. In vivo evaluation of acute and chronic pain activities of the new compounds were carried out by applying tail immersion and formalin tests on mice.

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