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  1. Sep 8, 2020 · Introduction: More than 50% of patients with uveal melanoma end up developing metastases. Currently, there is no standard first-line treatment that facilitates proper management of the metastatic disease.

  2. Nov 13, 2021 · Uveal melanoma (UM) is characterized by relatively few, highly incident molecular alterations and their association with metastatic risk is deeply understood.

    • Ernesto Rossi, Michela Croce, Francesco Reggiani, Giovanni Schinzari, Giovanni Schinzari, Marianna A...
    • 10.3390/cancers13225684
    • 2021
    • Cancers (Basel). 2021 Nov; 13(22): 5684.
  3. Oct 11, 2021 · The therapeutic attitude in primary uveal melanoma must take into account the tumor size, location and extension, the visual function, the status of the fellow eye, the age and health status of the patient, and last but not least the presence of metastasis (18,19).

    • Daniel Constantin Branisteanu, Camelia Margareta Bogdanici, Daciana Elena Branisteanu, Minela Aida M...
    • 2021
  4. Apr 20, 2021 · Uveal melanoma comprises approximately 95 percent of melanomas arising from the eye, with the remainder arising mostly from the conjunctiva. The molecular pathogenesis, clinical presentation, and management of metastatic uveal melanoma are discussed here. The initial management of uveal and conjunctival melanomas is discussed separately.

  5. Apr 9, 2020 · Metastatic uveal melanoma (UM) in the liver can demonstrate periportal nodular growth patterns (top) or sinusoidal infiltrative growth patterns (bottom).

  6. Jan 4, 2023 · Key points. Advances in the understanding of the biology and immune microenvironment of uveal melanoma have improved prognostication and led to promising therapeutic strategies being tested in...

  7. Mar 1, 2024 · Even though there is no gold standard for the prognostication of patients with uveal melanoma, it is becoming increasingly clear that combining histo-pathological, patient-related and molecular prognostic markers allows a more accurate prediction of the metastatic risk than by using one parameter.

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