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Key points. Von Willebrand disease (VWD) occurs with equal frequency among men and women, affecting up to 1% of the general population. Women are more likely to experience symptoms of VWD because of the increased bleeding it causes during their menstrual periods, during pregnancy, and after childbirth.
May 1, 2017 · During pregnancy, hormonal influences lead to an increase in vWF and clotting factors VII, VIII, and X while anticoagulant factors (such as protein S) decrease, shifting hemostasis to a procoagulant state to compensate for anticipated hemorrhage during parturition. 3 Although vWF and FVIII levels rise and peak during the third trimester, women w...
- Caroline Berube, Brian Dietrich
- 2017
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Oct 26, 2021 · Many people with von Willebrand disease also have low levels of factor VIII, another protein that helps in clotting. Factor VIII is involved in another inherited clotting disorder called hemophilia. But unlike hemophilia, which mainly affects males, von Willebrand disease affects males and females and is usually milder.
General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9, 17, 27, 31, treatment options should be planned at the beginning of pregnancy.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
Mar 31, 2017 · Men and women develop von Willebrand disease at the same rate. But women are more likely to experience symptoms and complications due to the increased risk of bleeding during menstruation...
May 11, 2024 · In addition to genetic causes, certain factors can also worsen the symptoms of Von Willebrand Disease. These include hormonal changes, such as those occurring during puberty or pregnancy, as well as certain medications like aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
