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A standard definition of post-partum hemorrhage (PPH) considers the threshold of >500 mL blood loss for vaginal delivery and of >1,000 mL for caesarean section 13. Rates of PPH in Western Countries based on hospital discharge may range from 3 to 6%, while cases needing blood transfusion are as low as 1 % 10.
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Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
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May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
May 15, 2024 · Pregnancy and childbirth. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman's health care providers to be aware that she has VWD so that plans can be made for a ...
Dec 10, 2021 · VWD is a genetically and clinically heterogeneous bleeding disorder caused by a deficiency or an abnormality in the function of von Willebrand factor. Understanding inheritance pattern, hemostatic response to pregnancy, and response to treatment is essential for provision of individualized obstetric care and optimal outcome.
Jul 1, 2014 · Attention deficit hyperactivity disorder (ADHD) is estimated to affect 4.4% of adults in the United States ( 1 ). It is associated with an elevated risk of poorer general and mental health, substance abuse, impaired work performance, and financial distress ( 2 ). Approximately half of adults who had childhood ADHD continue to have the disorder ...
- Marlene P. Freeman
- 2014
Apr 16, 2024 · VON WILLEBRAND DISEASE OVERVIEW. von Willebrand disease (VWD) is a bleeding disorder. It can be inherited or, less commonly, it can develop later in life (this type of VWD is not heritable and is referred to as acquired von Willebrand syndrome [AVWS]). The amount of bleeding and need for treatment varies from person to person, with some never ...
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
