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Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia (AML). It happens when there are too many of the blood-forming cells called promyelocytes in the blood and bone marrow. A buildup of promyelocytes leads to a shortage of other kinds of blood cells, including red cells, white cells, and platelets.
Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancer of the white blood cells. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes.
Jun 26, 2023 · Acute promyelocytic leukemia is a distinguished subset of acute myeloid leukemia which is characterized by fusion gene transcript PML-RAR-alpha and high cure rates with treatment. This entity was first described in 1957 in patients with severe bleeding tendencies, fibrinolysis, rapid deterioration of the clinical status, and presence of ...
Apr 11, 2019 · Together with providing current indications on genetic diagnosis, modern risk-adapted frontline therapy, and salvage treatment, the review contains specific recommendations for the identification and management of the most important complications such as the bleeding disorder APL differentiation syndrome, QT prolongation, and other all- trans re...
Acute promyelocytic leukemia (APL) is a rare cancer affecting the blood and bone marrow. It occurs primarily in middle-aged adults, but it also can affect children. Prompt diagnosis and treatment reduce symptoms long-term (remission) and often cure APL.
Share. Acute promyelocytic leukemia (APL) is treated differently than other forms of acute myeloid leukemia. Many people with APL are first treated with a drug called all-trans-retinoic acid (ATRA), also called tretinoin (Vesanoid®). ATRA is given in combination with another drug called arsenic trioxide (Trisenox®).
Oct 4, 2021 · October 4, 2021 by Josh Farkas. CONTENTS. Rapid Reference. Primer. Basic physiology of APL. Why APL is important in critical care. Diagnosis. Epidemiology. Clinical presentation. Diagnostic studies. Treatment. Early initiation of ATRA. Coagulopathy of APL. Differentiation syndrome. Sepsis. Complications from arsenic trioxide. Pseudotumor cerebri.
