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Apr 2, 2024 · What are the symptoms of acute promyelocytic leukemia? Acute promyelocytic leukemia (APL) symptoms develop when your bone marrow can’t make normal numbers of red blood cells, white blood cells and platelets. If you have low blood cell levels (pancytopenia), you may develop serious symptoms, including anemia, bleeding issues and infections ...
- Induction
- Consolidation
- Maintenance
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The induction stage aims to reduce the number of APL cells, ultimately leading to remission. Remission is when there are no or very low levels of cancerous cells. The drug all-trans retinoic acid (ATRA) can help promyelocytes mature into white blood cells by eliminating the PML-RARα protein. As a stand-alone treatment, ATRA treatment can lead to re...
Consolidation can help keep a person in remission from APL. It may also help remove any remaining APL cells. A person will generally receive the same drugs that they had during the induction phase. However, the dosage or timing of their treatment may change. The consolidation phase usually takes several monthsTrusted Sourcedepending on what treatme...
If a person has a higher risk of their APL returning, they may need further treatmentTrusted Sourceafter consolidation. In maintenance therapy, a person receives lower dosages of drugs over a longer period. The most common treatments for maintenance therapy are ATRA alone or ATRA with chemotherapy — either 6-mercaptopurine (6-MP), methotrexate, or ...
APL is a rare form of AML that affects the bone marrow and blood cells. Learn about the symptoms, such as bleeding, fever, and weight loss, and the treatment options, such as ATRA, ATO, and chemotherapy.
May 17, 2023 · Acute promyelocytic leukemia (APL) is a blood cancer characterized by a marked increase in a type of immature white blood cells known as promyelocytes. It develops in about 600 to 800 individuals each year in the United States, most often in adults around the age of 40 but also in children.
Symptoms of APL. The symptoms of APL are due to the shortage of normal blood cells. They include fevers, fatigue, loss of appetite, and frequent infections. People with APL are also at an increased risk of bleeding and forming blood clots.
Mar 29, 2022 · Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). Learn about APL symptoms, causes, treatment, survival rate, and more.
What are the symptoms of acute promyelocytic leukemia? If your child has APL, the following symptoms may be present: Bleeding that is hard to stop, even from a small cut; Blood in the urine; Heavy nosebleeds; Bleeding gums and easy bruising; Fever and infections; Low red blood cell count; Paleness; Tiring easily; Poor appetite; Unexplained ...
Aug 5, 2021 · Acute promyelocytic leukemia is a relatively rare type of leukemia. Learn the symptoms, causes, treatments, and outlook for this very treatable form of leukemia.
