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Aug 31, 2023 · Dissociative disorders are mental health conditions that involve experiencing a loss of connection between thoughts, memories, feelings, surroundings, behavior and identity. These conditions include escape from reality in ways that are not wanted and not healthy.
Dec 8, 2022 · Users report dissociative and hallucinogenic effects similar to those of ketamine, but more powerful (five times more than ketamine and three times more than methoxetamine). Oral doses are reportedly between 6 and 12 mg [ 138 , 139 ].
- 10.3390/ijms232415574
- 2022/12
- Int J Mol Sci. 2022 Dec; 23(24): 15574.
Jan 1, 2016 · All arylcyclohexamines exhibit dissociative effects due to their noncompetitive antagonism of glutamate receptors of the NMDA subtype . They were initially sought after as an alternative to more traditional anesthetic agents but subsequently abused recreationally in pursuit of these same effects.
Sep 26, 2017 · Objective: Dissociation is a complex, ubiquitous construct in psychopathology. Symptoms of dissociation are present in a variety of mental disorders and have been connected to higher burden of illness and poorer treatment response, and not only in disorders with high levels of dissociation. This meta-analysis offers a systematic and evidence-based study of the prevalence and distribution of ...
- Lisa Lyssenko, Christian Schmahl, Laura Bockhacker, Ruben Vonderlin, Martin Bohus, Nikolaus Kleindie...
- 2018
Antagonism of the NMDA receptor confers anesthetic, anticonvulsant, neuroprotective, and dissociative effects; blockade of the dopamine transporter mediates stimulant and euphoriant effects as well as psychosis in high amounts; and activation of the μ-opioid receptor causes analgesic and euphoriant effects.
Nov 1, 2019 · Dissociative experiences and symptoms have sparked intense scrutiny and debate for more than a century. Two perspectives, the trauma model (TM), which postulates a direct and potent causal link between trauma and dissociation, and the sociocognitive model (SCM), which emphasizes social and cognitive variables (e.g., fantasy-proneness, media influences, suggestibility, suggestion, cognitive ...
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Jan 30, 2017 · While the precise neurobiological underpinnings of dissociation remain elusive, neuroimaging studies in disorders, characterized by high dissociation (e.g., depersonalization/derealization disorder (DDD), dissociative identity disorder (DID), dissociative subtype of posttraumatic stress disorder (D-PTSD)), have provided valuable insight into bra...
