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1. • • ACH derivatives have an antagonistic activity against the N-methyl-D-aspartate receptor, which leads to dissociative effects (dissociation of body and mind).
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     Arylcyclohexylamine Derivatives: Pharmacokinetic ...

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   Are arylcyclohexamines dissociative?

   • Policies and ethics Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1). They all exhibit dissociative...

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   Are arylcyclohexamines agonists?

   • As mentioned, the arylcyclohexamines are weak agonists at opioid receptors; however, at usual anesthetic and recreational doses, this is not thought to contribute to their analgesic effect; further, their analgesic effects are not reduced by the administration of naloxone [ 160, 161 ].

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   Are arylcyclohexamines addictive?

   • The stimulatory effects of the arylcyclohexamines on dopaminergic and serotonergic transmission in the central nervous system, via both inhibition of amine transporters and via direct agonist activity at D 2 and 5-HT 2A receptors, are responsible for their addictive properties [ 151 – 153 ].

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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3. www.ncbi.nlm.nih.gov › pmc › articlesArylcyclohexylamine Derivatives: Pharmacokinetic,...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 8, 2022 · ACH derivatives have an antagonistic activity against the N-methyl-D-aspartate receptor, which leads to dissociative effects (dissociation of body and mind). Synthetic ketamine derivatives produced in Asia are now arriving in Europe, where most are not listed as narcotics and are, thus, legal.

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4. en.wikipedia.org › wiki › ArylcyclohexylamineArylcyclohexylamine - Wikipedia

   en.wikipedia.org › wiki › Arylcyclohexylamine

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   Antagonism of the NMDA receptor confers anesthetic, anticonvulsant, neuroprotective, and dissociative effects; blockade of the dopamine transporter mediates stimulant and euphoriant effects as well as psychosis in high amounts; and activation of the μ

   Compound	Aryl Substituent	N Group	Cyclohexyl Ring
   2-HO-PCP	Phenyl	Piperidine	2-Hydroxy
   2-Me-PCP	Phenyl	Piperidine	2-Methyl
   2-MeO-PCP	Phenyl	Piperidine	2-Methoxy
   2-Keto-PCP	Phenyl	Piperidine	2-Keto

   See full list on en.wikipedia.org

5. link.springer.com › referenceworkentry › 10Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   Jan 1, 2016 · Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1). They all exhibit dissociative...

6. www.sciencedirect.com › science › articleArylcyclohexamines - ScienceDirect

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   Jan 1, 2022 · Arylcyclohexamines are a group of substances that exhibit dissociative effects due primarily to antagonism of the N-methyl-d-aspartate (NMDA) receptor. Many arylcyclohexamines have been studied in animal and human populations as effective alternatives to traditional inhalational and intravenous anaesthetic agents, and have now become drugs of ...

7. mdpi-res.com › d_attachment › ijmsArylcyclohexylamine Derivatives: Pharmacokinetic ...

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   Dec 8, 2022 · dissociative effects. The ACH family encompasses three main subfamilies: ketamine-like molecules, phencyclidine-like (PCP-like) molecules and eticyclidine-like (PCE-like) molecules. These compounds are mainly derived through modification of the aryl ring, i.e., through the addition of an alkyl chain or substitutions of the amine group (Figure1).

8. tripsitter.com › psychedelics › arylcyclohexylaminesArylcyclohexylamines - Tripsitter

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   Jan 13, 2024 · Other drugs with dissociative effects include nitrous oxide and xenon gas, MK-801, and dextromethorphan (DXM). Alcohol, gamma-hydroxybutyrate (GHB), and some benzodiazepines can also exert a dissociative-like effect — but these drugs are nowhere near as strong as the others mentioned above.

9. pubmed.ncbi.nlm.nih.gov › 36555217Arylcyclohexylamine Derivatives: Pharmacokinetic ...

   pubmed.ncbi.nlm.nih.gov › 36555217

   Dec 8, 2022 · First used mainly for their pharmacological properties in anesthesia, their recreational use is increasing. ACH derivatives have an antagonistic activity against the N-methyl-D-aspartate receptor, which leads to dissociative effects (dissociation of body and mind).