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    • Sepsis and septic shock: Guideline-based management
      • In 2004, the Surviving Sepsis Campaign guidelines adopted those definitions, which led to the development of a protocol-driven model for sepsis care used worldwide. 6 The US Centers for Medicare and Medicaid Services (CMS) followed suit, defining sepsis as the presence of at least 2 SIRS criteria plus infection; severe sepsis as sepsis with organ dysfunction (including serum lactate > 2 mmol/L); and septic shock as fluid-resistant hypotension requiring vasopressors, or a lactate level of at...
      www.ccjm.org › content › 87/1/53
  1. May 25, 2021 · focuses on adult patients. It uses the Sepsis -2 definition which includes both severe sepsis and septic shock, both on admission or at any time during the patient’s hospital stay. The numerator is the number of inpatient mortalit ies; the denominator is all patients with a diagnosis of severe sepsis or septic shock.

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  3. Severe sepsis and septic shock involve an inflammatory immune response to infection and are associated with high rates of mortality. CMS aims to improve patient outcomes by encouraging proactive, comprehensive management of the infection.

  4. Jul 10, 2017 · The CMS sepsis core measures detail different clinical criteria and parameters that define the qualifications for severe sepsis and septic shock. The CMS definition of severe sepsis is an infection or suspected infection with two or more SIRS criteria plus one sign of organ dysfunction ( Table 3 ).

    • Annahieta Kalantari, Haney Mallemat, Scott D. Weingart
    • 2017
  5. Under the new definition, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, where organ dysfunction is defined as an increase in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. 1.

    • Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annan...
    • 2016
  6. Jan 1, 2020 · The CMS definition continues to recommend SIRS for sepsis identification, while Sepsis-3 uses sequential organ failure assessment (SOFA) or the quick version (qSOFA) to define sepsis (described below).

    • Siddharth Dugar, Chirag Choudhary, Abhijit Duggal
    • 2020
  7. Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection.”1 While sepsis is often attributed to bacterial infections, sepsis may result from infections of any etiology, including viral infections such as COVID-19.

  8. While some studies have looked at optimizing therapies, the “Sepsis – 3: The Third International Consensus Definitions for Sepsis and Septic Shock,” which was presented at the 45th Annual SCCM Critical Care Congress in 2016 attempted to redefine sepsis and its categories.1. Sepsis holds a high mortality when not properly treated.

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