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Nov 4, 2021 · The Delta variant also shifted which states were hit hardest by COVID-19 deaths. Before July, New Jersey was the worst-hit state for cumulative COVID-19 death rates, with 297 deaths per 100,000 people. But the Delta surge drove cumulative death rates in Mississippi, Alabama, and Louisiana over 300 per 100,000 residents.
Jul 31, 2021 · By Lauren Leatherby July 31, 2021. The highly contagious Delta variant is now responsible for almost all new Covid-19 cases in the United States, and cases are rising rapidly. For the first...
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Dec 20, 2021 · Death Rates from January 3 to September 4, 2021. Death rates per 100,00 person-weeks were 0.76 (95% CI, 0.75 to 0.78) across all ages and vaccine products during January 3 to September 4,...
- Overview
- Discussion
- References
On January 21, 2022, this report was posted online as an MMWR Early Release.
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COVID-19 vaccines reduced risks for SARS-CoV-2 infection and COVID-19–associated death during periods of Delta variant predominance and infection risk during Omicron variant emergence. Because of reporting lags, the influence of the Omicron variant on COVID-19–associated deaths by vaccination status in December could not be evaluated. Substantial case rate increases were recorded among unvaccinated and vaccinated persons when Omicron became the predominant variant in December, resulting in decreased IRRs and declining crude VE estimates (7). IRRs and VE were higher among persons who were fully vaccinated and had received a booster dose than among fully vaccinated persons who had not received a booster dose for cases and deaths during the period of Delta predominance and for cases during the period of Omicron emergence in December. The added benefits of booster doses were especially prominent among persons aged 50–64 and ≥65 years.
The findings in this report are subject to at least five limitations. First, booster doses could not be distinguished from additional primary doses administered to immunocompromised persons, which could result in reduced IRRs because of lower VE in this population. Second, this ecological study lacked multivariable adjustments, and causality could not be determined. Possible differences in testing, infection-derived immunity, waning of vaccine-derived immunity, or prevention behaviors by age and vaccination status might partly explain differences in rates between groups; trends are likely affected by temporal changes in testing or reporting. Third, national variant prevalence estimates were used, but prevalence differed by jurisdiction over time. Fourth, variable data linkage completeness might have resulted in misclassifications (e.g., booster doses not being linked to primary series) that could influence IRR estimates (5). Finally, these data represent 62% of the overall U.S. population, and therefore might not be generalizable.
1.Scobie HM, Johnson AG, Suthar AB, et al. Monitoring incidence of COVID-19 cases, hospitalizations, and deaths, by vaccination status—13 US jurisdictions, April 4–July 17, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1284–90. https://doi.org/10.15585/mmwr.mm7037e1 PMID:34529637
2.Paz-Bailey G, Sternberg M, Kugeler K, et al. Covid-19 rates by time since vaccination during Delta variant predominance. NEJM Evidence 2021. Epub December 20, 2021. https://doi.org/10.1056/EVIDoa2100057
3.CDC. Rates of COVID-19 cases and deaths by vaccination status. Atlanta, GA: US Department of Health and Human Services, CDC; 2021. https://covid.cdc.gov/covid-data-tracker/#rates-by-vaccine-status
4.CDC. Rates of laboratory-confirmed COVID-19 hospitalizations by vaccination status. Atlanta, GA: US Department of Health and Human Services, CDC; 2021. https://covid.cdc.gov/covid-data-tracker/#covidnet-hospitalizations-vaccination
5.Fast HE, Zell E, Murthy BP, et al. Booster and additional primary dose COVID-19 vaccinations among adults aged ≥65 years—United States, August 13, 2021–November 19, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1735–9. https://doi.org/10.15585/mmwr.mm7050e2 PMID:34914672
6.CDC COVID-19 Response Team. SARS-CoV-2 B.1.1.529 (Omicron) variant—United States, December 1–8, 2021. MMWR Morb Mortal Wkly Rep 2021;70:1731–4. https://doi.org/10.15585/mmwr.mm7050e1 PMID:34914670
Sep 16, 2021 · Across 13 U.S. jurisdictions, incidence rate ratios for hospitalization and death changed relatively little after the SARS-CoV-2 B.1.617.2 (Delta) variant reached predominance, suggesting high, continued vaccine effectiveness against severe COVID-19.
- Heather M. Scobie, Amelia G. Johnson, Amitabh B. Suthar, Rachel Severson, Nisha B. Alden, Sharon Bal...
- 2021
Excess mortality: Cumulative deaths from all causes compared to projection based on previous years Percentage; Excess mortality: Cumulative deaths from all causes compared to projection based on previous years, per million people; Excess mortality: Deaths from all causes compared to average over previous years P-scores, average baseline
Aug 10, 2021 · But last week, the agency noted that those figures did not reflect new data involving the Delta variant and said it was actively working to update them. Only about 50 percent of people in the...
