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1. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.

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3. jbiomedsci.biomedcentral.com › articles › 10Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com › articles › 10

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   Apr 22, 2024 · HnRNPs (heterogeneous nuclear ribonucleoproteins), for instance, have been shown to regulate host mRNA expression in response to dengue infection. Modulation of these RBPs by dengue infection can impact mRNA transport and localization, potentially influencing viral replication and pathogenesis.

4. www.ncbi.nlm.nih.gov › pmc › articlesProduction, Transmission, Pathogenesis, and Control of Dengue ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...

   • DOI: 10.1155/2021/4224816
   • Published: 2021

   • Publication: Biomed Res Int. 2021; 2021: 4224816.

5. People also ask

   What causes severe manifestations of dengue virus disease?

   • The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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   How does a dengue virus interact with the host cellular machinery?

   • During dengue infection, the virus interacts with the host cellular machinery responsible for 5’ capping. DENV employs multiple strategies to hijack and manipulate this process. For instance, the virus sequesters essential host factors involved in capping, such as the cap-binding complex and associated enzymes.

   Dengue virus pathogenesis and host molecular machineries

   jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01030-9

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   What is the pathogenesis of dengue?

   • The pathogenesis of dengue was attributed to various viral and host factors such as non-structural protein 1 (NS1) viral antigen, DENV genome variation, subgenomic RNA, antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies and autoimmunity.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

   See all results for this question

6. www.nejm.org › doi › fullDengue | New England Journal of Medicine

   www.nejm.org › doi › full

   Apr 12, 2012 · DOI: 10.1056/NEJMra1110265. VOL. 366 NO. 15. Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a ...

7. www.nature.com › articles › nmicrobiol201750Viral pathogenesis: Dengue virus takes on cGAS - Nature

   www.nature.com › articles › nmicrobiol201750

   DENV infection leads to a loss of mitochondrial membrane integrity, which triggers the release of mitochondrial DNA into the cytosol, inducing the activation of the DNA sensor cGAS and,...

   • Author: Michiel van Gent, Michaela U. Gack

   • Publish Year: 2017

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9. www.sciencedirect.com › science › articleMolecular mechanisms in the pathogenesis of dengue infections

   www.sciencedirect.com › science › article

   May 1, 2024 · We discuss the molecular mechanisms of dengue pathogenesis, the gaps in our knowledge, and recent advances, as well as the most crucial questions to be answered to enable the development of therapeutics, biomarkers, and vaccines.

10. www.sciencedirect.com › science › articleDengue virus infection – a review of pathogenesis, vaccines ...

    www.sciencedirect.com › science › article

    Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...