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Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.
Sep 20, 2019 · Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
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Apr 23, 2024 · Most people with dengue have mild or no symptoms and will get better in 1–2 weeks. Rarely, dengue can be severe and lead to death. If symptoms occur, they usually begin 4–10 days after infection and last for 2–7 days. Symptoms may include: high fever (40°C/104°F) severe headache. pain behind the eyes.
Dec 15, 2021 · Phospholipase A 2, a chemical constituent of Crotalus durissus terrificus venom, was inhibited dengue virus and yellow fever virus infection in Vero cells, inducing a partial exposure of genomic RNA through glycerophospholipids cleavage . Tomatidine has inhibited dengue virus mainly at late stages of infection towards all dengue virus serotypes ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
A recent systematic review and meta-analysis showed that allergic symptoms are one of the core symptoms that are highly associated with dengue severity. Mechanism of infection. Dengue virus' (DENV) E envelope protein binds to a cellular receptor. The exact nature of the cellular receptor has not been fully elucidated.
Oct 25, 2010 · A research team led by Dr. Leonid V. Chernomordik at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) set out to investigate how the dengue virus fuses with its target membranes. The researchers tagged dengue virus and cell membranes with fluorescent probes that glow when the virus and membranes fuse.
The lack of a suitable animal model, a proper mechanistic study in pathogenesis, and ADE are the main hindrances in vaccine development. This review summarizes the current knowledge on DENV epidemiology, biology, and disease aetiology in the context of prevention and protection from dengue virus disease.
