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Mar 8, 2023 · Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.
- 10.3390/v15030705
- 2023/03
- Viruses. 2023 Mar; 15(3): 705.
Oct 5, 2021 · Dengue virus belongs to the class of RNA viruses and subclass of enveloped single-stranded positive-sense RNA virus. It causes dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS), where DHF and DSS are life-threatening.
- Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh
- 2021
Apr 18, 2023 · Currently, the drugs are in phase 1 (NCT05366439) and phase 2 (NCT05466240) double-blind, randomized, placebo-controlled studies to assess the safety and antiviral activity in the dengue human challenge model and in dengue patients, respectively.
- 10.1007/s40506-023-00263-w
- 2023
Sep 20, 2019 · In this chapter we will discuss the evolution of virus and its vector, epidemiology of dengue, molecular and genomic structure of DENV, their pathogenesis, immune response of the host to the infection, laboratory diagnosis, management, and recent developments in dengue drug and vaccine development.
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
Nov 19, 2023 · According to the World Health Organization (WHO) dengue guideline, the spectrum of DENV infection can vary from undifferentiated febrile illness or asymptomatic infection to more serious manifestations, including dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF). Methodology.
Aug 15, 2019 · Abstract. Dengue is the most important arthropod-borne viral disease of humans, with more than half of the global population living in at-risk areas. Despite the negative impact on public health, there are no antiviral therapies available, and the only licensed vaccine, Dengvaxia ®, has been contraindicated in children below nine years of age.
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Jul 8, 2006 · Here, we review the magnitude of the burden of dengue disease in endemic areas, highlight the limitations of the current WHO dengue classification scheme, and propose a solution for developing a more robust system.
