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1. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · Anti-DENV drug candidates such as chloroquine, prednisolone, lovastatin, and celgosivir have undergone clinical trials but failed to reduce viremia significantly to provide any significant beneficial effects [ 17, 18, 19, 20 ].

   • Dengue Virus

     In this chapter we will discuss the evolution of virus and...

   • An Overview

     Dengue is an acute febrile disease caused by the...

2. www.drugs.com › condition › dengue-feverList of Dengue Fever Medications - Drugs.com

   www.drugs.com › condition › dengue-fever

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   Compare risks and benefits of common medications used for Dengue Fever. Find the most popular drugs, view ratings and user reviews.

3. Videos

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     Dengue Fever | Pathophysiology, Symptoms, Diagnosis & Treatment

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     Life Cycle of the Dengue Fever Virus — HHMI BioInteractive Video

     Jun 11, 2014

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4. www.ncbi.nlm.nih.gov › pmc › articlesDengue Virus - PMC - National Center for Biotechnology ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 20, 2019 · In this chapter we will discuss the evolution of virus and its vector, epidemiology of dengue, molecular and genomic structure of DENV, their pathogenesis, immune response of the host to the infection, laboratory diagnosis, management, and recent developments in dengue drug and vaccine development.

   • Author: Amudhan Murugesan, Mythreyee Manoharan
   • Published: 2020

   • DOI: 10.1016/B978-0-12-819400-3.00016-8

5. www.ncbi.nlm.nih.gov › pmc › articlesDengue viruses – an overview - PMC - National Center for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 30, 2013 · Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the family, genus flavivirus ( 1 ). All four DENV serotypes have emerged from sylvatic strains in the forests of South-East Asia ( 2 ).

   • Author: Anne Tuiskunen Bäck, Åke Lundkvist
   • DOI: 10.3402/iee.v3i0.19839

   • Publish Year: 2013
   • Published: 2013

6. emedicine.medscape.com › article › 215840-medicationDengue Medication: Analgesics, Volume Expanders, Vaccines ...

   emedicine.medscape.com › article › 215840-medication

   Nov 16, 2022 · Class Summary. Elicits dengue-specific immune responses against the 4 dengue virus serotypes (ie, serotypes 1, 2, 3, and 4).

7. pubmed.ncbi.nlm.nih.gov › 31128447Recent update on anti-dengue drug discovery - PubMed

   pubmed.ncbi.nlm.nih.gov › 31128447

   Aug 15, 2019 · Here, we review anti-DENV molecules and their drug targets that have been published within the past five years (2014-2018). Further, we discuss their probable mechanisms of action and describe a role for classes of clinically approved drugs and also an unclassified class of anti-DENV agents.

8. People also ask

   What is a dengue serotype?

   • Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the family, genus flavivirus ( 1 ). All four DENV serotypes have emerged from sylvatic strains in the forests of South-East Asia ( 2 ).

   Dengue viruses – an overview - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC3759171/

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   What is a dengue virus (DENV)?

   • Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity.

   Dengue viruses – an overview - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC3759171/

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   Can a single drug be effective against all four dengue virus serotypes?

   • Conclusions: This work strengthens the notion that a single drug mol.can be effective against all four dengue virus serotypes. The mol. MB21 could be a potential candidate for 'hit-to-lead' optimization, and may pave the way towards developing a pan-dengue virus antiviral drug.

   The Medicinal Chemistry of Dengue Virus

   pubs.acs.org/doi/10.1021/acs.jmedchem.5b01653

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   What is a small molecule inhibitor of dengue virus type 2 protease?

   • Raut R., Beesetti H., Tyagi P., Khanna I., Jain S.K., Jeankumar V.U., Yogeeswari P., Sriram D., Swaminathan S. A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture. Virol. J. 2015;12:16. doi: 10.1186/s12985-015-0248-x.

   Molecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov/pmc/articles/PMC10056858/

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   How many non-structural proteins are in a dengue virus?

   • (Society for General Microbiology) Dengue virus, a member of the family Flaviviridae of pos.-strand RNA viruses, has7 non-structural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5. Except for enzymic activities contained within NS3 and NS5, the roles of the other proteins in virus replication and pathogenesis are not well defined.

   The Medicinal Chemistry of Dengue Virus

   pubs.acs.org/doi/10.1021/acs.jmedchem.5b01653

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   Can synergistic drug combinations be used for the treatment of dengue?

   • The combinations of antivirals with different mechanisms of action could be evaluated to develop synergistic drug combinations for the treatment of dengue at any stage of the infection.

   Molecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov/pmc/articles/PMC10056858/

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9. pubs.acs.org › doi › 10The Medicinal Chemistry of Dengue Virus | Journal of ...

   pubs.acs.org › doi › 10

   107. LEARN ABOUT THESE METRICS. Add to. Export RIS. PDF (3 MB) Get e-Alerts. SUBJECTS: Antimicrobial agents, Assays, Infectious diseases, Inhibitors, Peptides and proteins. Abstract. The dengue virus and related flaviviruses are an increasing global health threat.